Profhilo treatment in Marylebone at Dr Joney De Souza Clinic boosts hydration, improves elasticity and restores youthful firmness. This powerful skin booster remodels and rejuvenates the skin for natural, long lasting radiance. Book your consultation today.
Profhilo Treatment Summary
Profhilo is an award-winning skin bio-remodelling treatment now available at Dr Joney De Souza Skin and Laser Clinic. This unique injectable treatment uses high concentrations of natural Hyaluronic Acid (HA), enabling its powerful hydrating properties to stimulate tissue, encouraging long-lasting neocollagenesis. Profhilo can help to improve skin tone, texture, elasticity, firmness, hydration and radiance.
Profhilo works to rejuvenate and nourish dermal cells, providing long-lasting improvements to the health and appearance of your skin for up to 4-6 months after treatment. By boosting the skin’s own collagen production, skin is left feeling firm, hydrated and glowing!

Our patients return to us year after year for natural, balanced results. Every review reflects our commitment to precision, safety and a personalised approach to aesthetic care.
Botox has become one of the most trusted and widely used treatments for softening expression lines and maintaining a fresher, more relaxed appearance. Increasingly, people are choosing to start treatment earlier as a preventative approach, addressing fine lines before they become deeply set.
Rather than altering facial shape or expression, Botox works by calming the overactive muscles that contribute to frown lines, forehead creases and crow’s feet over time. When performed with precision and a light hand, it helps preserve natural movement while slowing the formation of future wrinkles. At Dr Joney De Souza Clinic, the focus is always on subtlety, balance and long term skin health, using advanced techniques to achieve results that look effortless, not obvious.

Profhilo is an innovative skin remodelling treatment designed to improve hydration, elasticity and overall skin quality. It contains one of the highest concentrations of pure hyaluronic acid available and works by stimulating collagen and elastin production rather than adding volume or altering facial structure.
Profhilo is a non-surgical, quick and safe procedure. Small, precise injections are placed just beneath the skin where the product spreads naturally across the tissue, delivering deep hydration and improving firmness. It is especially effective for areas that show early signs of ageing such as the cheeks, lower face, neck and décolletage.
There is minimal downtime. You may experience slight redness, swelling or small bumps at the injection points, which typically settle within a few hours. Results develop gradually over the following weeks as the skin becomes smoother, tighter and more radiant. Most patients complete an initial course of two sessions four weeks apart, with results lasting around six months depending on individual skin condition and lifestyle.
Profhilo works to improve your complexion by nourishing the dermal cells, resulting in radiant and rejuvenated skin. It can also help to combat the signs of ageing before they appear thanks to its intense hydrating capabilities. However, the most evident changes are seen when treating the appearance of lines, wrinkles, sagging, thinning and crepe-like skin. Profhilo effectively lifts and tightens the skin increasing firmness and elasticity with results that continue to improve for up to 6 months.
You will be invited for a medical consultation to assess your suitability for Profhilo treatment.
Profhilo is most commonly used on the face, but it can also treat:
Neck
Décolletage
Hands
Upper arms
Areas of crepey or lax skin
It is ideal for improving texture, hydration and elasticity.
Most patients require an initial course of two treatments, spaced four weeks apart.
Some may benefit from a third session depending on their skin condition. Maintenance every 6 months is recommended for ongoing results.
Discomfort is minimal. The injections are quick, and most patients describe only a brief stinging sensation. A topical anaesthetic can be applied if needed.
Downtime is very minimal. You may notice small bumps, redness or swelling at the injection points, which usually settle within a few hours. Normal daily activities can be resumed right away.
You may notice early hydration improvements within a few days. The full skin remodelling effect develops 2–6 weeks after the second treatment, as collagen and elastin production increases.
Results typically last around 6 months, depending on age, skin quality and lifestyle. Regular maintenance treatments help maintain long-term skin improvement.
Yes. Profhilo works beautifully alongside dermal fillers, Botox, microneedling, skin boosters and energy-based treatments. Dr Joney will advise on the best combination for your skin goals.
Profhilo is suitable for a wide range of skin types and ages, particularly those experiencing early signs of ageing, dehydration or loss of firmness. A consultation is required to ensure suitability, especially if you are pregnant, breastfeeding or have certain medical conditions.
No. Profhilo does not change facial structure or add volume. It improves skin quality from within, giving a healthier, fresher and more radiant appearance while keeping your natural features intact.
Every Profhilo treatment at Dr Joney De Souza Clinic begins with a thorough consultation. During this appointment, Dr Joney will take time to understand your skin goals, assess your hydration levels, elasticity and overall skin quality, and identify the areas that will benefit most from treatment. He will explain how Profhilo works, what improvements you can expect, and whether combining it with other treatments may help achieve optimal results.
Once your personalised plan is agreed, the skin is gently cleansed and a topical anaesthetic may be applied to ensure comfort. Using precise injection techniques, Dr Joney administers small amounts of Profhilo into a series of bio-aesthetic points just beneath the skin. The treatment is quick and designed to distribute the hyaluronic acid evenly across the tissue, stimulating collagen and elastin for a naturally refreshed, hydrated and lifted appearance. Discomfort is minimal and there is no significant downtime.
Following your Profhilo treatment, you can return to most daily activities straight away. You may notice slight redness, swelling or small visible bumps at the injection sites. These are completely normal and typically disappear within a few hours to 24 hours as the product begins to disperse through the skin.
Dr Joney will provide personalised aftercare advice, which may include avoiding strenuous exercise, heat treatments and applying pressure to the treated areas for 24 to 48 hours. As the active ingredients stimulate the skin’s natural repair processes, you will begin to notice improvements in hydration, smoothness and firmness over the following days. Results continue to develop after the second treatment session, usually performed four weeks later.
With regular maintenance every six months, your skin will remain brighter, more elastic and naturally rejuvenated, while maintaining the soft, subtle and refreshed look that Profhilo is known for.


You can rest assured that we only use the highest quality UK sourced products at our clinic, this includes only the most premium dermal fillers and the most advanced FDA approved technologies. With the highest levels of customer service and expertise, our focus is on you – just have a look at our amazing reviews.
All treatments consist of 1 session unless it is a package, which will have multiple sessions based on treatment.
All Pricing is in GBP.
| Area/Treatment | Prices with Dr Joney | Price with Associate |
|---|---|---|
Profhilo - 1 area | 475 | 400 |
Profhilo - 2 areas | 800 | 680 |
Profhilo - 3 areas | 1,000 | 850 |
Profhilo - Mouth area (‘smoker’s lines’) & Lower face | 1,650 | 1,400 |
Profhilo Body - 1 area | 475 | 400 |
Profhilo Body - 2 areas | 780 | 665 |
Based at 49 Blandford Street in Marylebone, Dr Joney De Souza Skin & Laser Clinic is known for its refined, personalised approach to aesthetic medicine. Under the expert care of Dr Joney, every treatment is tailored to enhance natural beauty and maintain long-term skin health.
Dr Joney will advise you on aftercare, such as avoiding strenuous exercise or massaging the area for 24 hours. Many patients choose to book a review appointment around two weeks later, where any fine-tuning can be carried out if necessary.
Results typically last between three to six months, depending on your individual response and the area treated. With regular maintenance treatments, you’ll notice smoother skin, softer lines, and a fresher, more relaxed appearance that still looks entirely natural.


Our team would love to hear from you. Whether you have questions, need guidance, or simply want to explore your treatment options, we’re here to support you every step of the way. Reach out in whichever way feels easiest