Regenerative exosome therapy in Marylebone, delivered during SkinPen microneedling for firmer, brighter skin. From £300. Book your consultation at Dr Joney De Souza.
If your skin looks tired, has lost some of its early firmness, or simply doesn’t bounce back the way it once did, exosome therapy works at the cellular level to signal repair. It suits a broad range of concerns rather than a single problem, and many patients choose it as an early regenerative step, supporting the skin before the signs of ageing become pronounced. At your consultation, your practitioner assesses your skin health and confirms whether these concerns can be improved:
Exosome therapy is at its best rebuilding genuine skin quality over time, strengthening and refreshing the skin from within across a course of sessions. If your priority is added volume or softening expression lines, we can pair it with complementary treatments for that.
Exosome therapy is one of the most advanced regenerative treatments in aesthetic medicine. At Dr Joney De Souza Clinic, exosomes are delivered during SkinPen microneedling, so the active messengers reach the deeper layers where they do their work. Rather than masking the surface, exosomes carry powerful biological signals that repair tissue, reduce inflammation and rebuild the skin from within.
Once absorbed through the microneedling channels, exosomes penetrate the skin’s deepest layers and transmit cell-stimulating messages, activating fibroblasts to produce significantly more collagen and elastin. Patients enjoy skin that looks brighter, firmer and healthier while still looking entirely like themselves.
Related treatments at Dr Joney De Souza: polynucleotides, SkinPen microneedling, PRP treatment and dull skin.
Every result below is a real Dr Joney De Souza patient. Use the slider to see the change. Results vary from person to person.
Exosomes are microscopic messenger particles that cells naturally release to communicate with one another. Packed with proteins, growth factors, lipids and nucleic acids, they act as biological couriers, carrying instructions that tell your skin cells to repair, renew and defend themselves. Applied to the skin through the fine channels created by SkinPen microneedling, these tiny vesicles reawaken the regenerative signalling that slows with age and prompt fibroblasts to produce up to 600 percent more collagen and 300 percent more elastin.
Exosomes are microscopic vesicles that cells release to communicate with one another. They carry proteins, growth factors, lipids and nucleic acids, acting as biological messengers that instruct surrounding skin cells to repair and renew. In effect, they reawaken the regenerative signalling that naturally slows as we age.
Once absorbed, exosomes transmit cell-stimulating messages directly to your fibroblasts, the cells responsible for building the skin’s supportive scaffolding. These fibroblasts can produce up to 600 percent more collagen and 300 percent more elastin, rebuilding firmness and resilience from within rather than on the surface.
Exosomes are small enough to penetrate the skin’s deepest layers and deliver their cargo directly to the cells that need it. At Dr Joney De Souza Clinic they are always delivered during SkinPen microneedling, which creates fine channels that help the particles travel deeper and integrate with your skin’s own repair processes.
Rather than relaxing muscle movement, exosomes improve the underlying health and structure of the skin itself. The two approaches address separate concerns, so they work as partners within a considered plan. Exosome therapy is a genuinely regenerative treatment, whereas anti-wrinkle injections target dynamic lines caused by expression.
Yes. Alongside stimulating collagen, exosomes carry anti-inflammatory signals that help settle reactive skin and conditions such as acne and rosacea. By improving communication between cells, they support healthier turnover and a calmer, more even complexion over time.
The exosomes used at Dr Joney De Souza Clinic undergo rigorous purification and testing, so they are biocompatible and integrate naturally with your skin’s repair processes. A regenerative treatment works at a cellular level, so product quality and correct technique matter enormously, which is why every stage is carefully overseen by the clinical team.
Every exosome treatment at Dr Joney De Souza Clinic follows a clear, considered path built around natural regeneration rather than a quick fix. Each stage is planned around your skin health, so you understand exactly what to expect from consultation through to aftercare.
Your consultation is with Dr Joney De Souza or Dr Mattia Parducci, who takes time to understand your skin goals, assess your overall skin health and discuss the concerns you would like to improve. Your practitioner explains how exosomes work, the regenerative effects you can expect and how they are delivered during SkinPen microneedling. Suitability is confirmed at this stage, so you leave with a clear, personalised plan.
The skin is gently cleansed and a topical numbing cream is applied for around 30 minutes, since exosomes are delivered alongside microneedling. Using precise technique, your practitioner then works the exosomes into the skin through the microneedling channels that carry them to the deeper layers. Discomfort is minimal, and most patients describe only a mild warmth throughout the 45-minute appointment.
You can usually return to normal activities straight away, though the skin may appear slightly pink for 24 to 48 hours from the microneedling. Because exosomes accelerate healing, this settles quickly. Your practitioner provides personalised aftercare advice and reviews your progress, recommending maintenance sessions to preserve your results.
Choosing the right clinic matters when your treatment works at a cellular level. Exosome therapy is a genuinely regenerative approach, and it rewards careful assessment, high-quality products and an experienced hand. Patients choose Dr Joney De Souza in Marylebone for the combination of medical expertise and a natural, balanced aesthetic.
“My ‘less is more’ approach has become the mainstay of my practice and clients appreciate that they will have natural looking results” Dr Joney De Souza, thesybarite.co
Exosome therapy at Dr Joney De Souza Clinic is delivered to a genuine medical standard. Carried out by Dr Joney De Souza or a member of our clinical team. Your consultation is with Dr Joney De Souza or Dr Mattia Parducci. Every plan begins with a thorough consultation, so you receive tailored advice, careful monitoring and a considered approach that prioritises long-term skin health over a quick fix.
Delivered this way, exosome therapy works with your skin’s own repair signals, helping it stimulate collagen and stay stronger and healthier over time, which is really what skin longevity is about.
Exosome therapy at Dr Joney De Souza Clinic starts from £300, with the final price depending on the number of treatment areas and whether it is delivered as part of a microneedling package. Every plan is personalised, and most patients are guided towards a course of three sessions for the strongest long-term results.
The right option depends on your skin health, goals and number of areas, so your exact plan and price are confirmed at your consultation with Dr Joney De Souza or Dr Mattia Parducci.
| Treatment | From (£) |
|---|---|
Exosome add-on (with microneedling) | 300 |
Face package | 650 |
Face and neck package | 750 |
Face, neck and décolletage package | 850 |
At Dr Joney De Souza Clinic, exosome therapy is delivered during SkinPen microneedling. The two are inseparable here, and for good reason. Microneedling creates fine channels in the skin, and those channels let the exosomes travel deeper to reach the fibroblasts that drive collagen and elastin production. The combination maximises regenerative stimulation and delivers a stronger, more even improvement than surface application ever could.
The two also support each other during recovery. Microneedling triggers the skin’s natural repair response while the exosomes calm inflammation and accelerate healing, so any redness settles more quickly. If you’re weighing up your options, exosomes work well alongside other regenerative treatments such as polynucleotides and PRP treatment, and your practitioner will explain how each fits your skin.
Below are the questions patients most often ask about exosome therapy at the Marylebone clinic. This is an advanced regenerative treatment, and understanding how it works helps you feel confident before you book. If your question isn’t answered here, the team is always happy to help.
Exosome therapy starts from £300, with the final price depending on the number of treatment areas and whether it is delivered as part of a microneedling package. Every plan is personalised, so your exact quote is confirmed at consultation. Most patients are advised to complete a course of three sessions for the best long-term results.
Most patients benefit from a course of three treatments, typically spaced two to three weeks apart. The regenerative effect builds progressively, so completing the full course gives the strongest and longest-lasting improvement. Maintenance sessions every few months can help preserve your results depending on your skin goals.
Downtime is minimal. Since exosomes are delivered during SkinPen microneedling, the skin may appear slightly pink or feel sensitive for 24 to 48 hours. Exosomes help accelerate healing and reduce inflammation, so these effects tend to settle quickly and most patients return to normal activities straight away.
Some patients notice an enhanced glow and improved hydration within a few days of treatment. The deeper regenerative results, such as improved firmness, texture and reduced redness, develop gradually over four to eight weeks. The full benefit continues to build as collagen and elastin production increases, especially across a complete course.
Yes, exosome therapy is very safe. The high-quality clinical exosomes used at the clinic undergo rigorous purification and testing, so they are biocompatible and integrate naturally with your skin’s own repair processes. Your practitioner assesses your suitability during consultation to make sure the treatment is right for you. It may not be recommended if you are pregnant or have an active skin infection, which is why the consultation comes first.
Exosome therapy is carried out by Dr Joney De Souza or a member of our clinical team. Your consultation is with Dr Joney De Souza or Dr Mattia Parducci. Regenerative treatments depend on precise technique and careful assessment, so having a doctor plan your treatment matters. Because exosomes are delivered during SkinPen microneedling, your session combines both in a single appointment.
Microneedling triggers the skin’s repair response by creating fine channels, while exosomes flood those channels with regenerative messengers that amplify the result. At Dr Joney De Souza Clinic the two are always combined, since exosomes are delivered during SkinPen microneedling to maximise collagen stimulation and speed up healing rather than being offered as a standalone option.
Exosome therapy improves the underlying health and structure of the skin, whereas anti-wrinkle injections relax the muscle movement that causes dynamic lines. The two address separate concerns, so they work as partners rather than rivals within a considered plan. Your practitioner recommends the right combination for your specific goals during consultation.
Patients return to Dr Joney De Souza year after year for natural, balanced results. Every review reflects the clinic’s commitment to precision, safety and a personalised approach to regenerative aesthetic care in Marylebone.
I highly recommend Dr. Joney and his clinic. I have been his patient for many years and he is definitely one of the best. His work is natural and subtle, he always puts the patient’s interest first and will never try to upsell unnecessary treatments.
Had an excellent experience today getting the Profhilo treatment done by Dr. Joney De Souza. The entire team was so friendly, and prepped me about what I should expect during and after the treatment.
Dr Joney is the most wonderful Dr, kind and caring and highly experienced. I feel safe in his care and trust his opinion 100%.
