Doctor-led Profhilo bio-remodelling in Marylebone, London. Boosts skin hydration, firmness and glow. From £400, course of 2. Book with Dr Joney De Souza.
Doctor-led Profhilo bio-remodelling injectable for skin laxity and deep hydration at Dr Joney De Souza Clinic, Marylebone
If your skin has started to look dull, thin or a little crepey, and creams no longer seem to make a difference, Profhilo is designed for you. It targets skin quality rather than shape, so it suits the person who wants to look fresher and healthier without adding volume or altering their features. At Dr Joney De Souza Clinic in Marylebone, we recommend Profhilo for patients experiencing:
Profhilo is at its best for fresher, healthier, better-quality skin that keeps your features your own. If your priority is restoring lost volume or contour, dermal fillers are the route, and your practitioner will plan that with you at consultation.
Profhilo is an injectable bio-remodelling treatment built from one of the highest concentrations of pure hyaluronic acid available. It is not a filler. Rather than adding volume or building contour, it spreads naturally beneath the skin from a small number of strategic points, delivering deep hydration and prompting your own collagen and elastin to rebuild from within.
At Dr Joney De Souza Clinic in Marylebone, we use Profhilo as a skin-quality treatment for patients who want better firmness, hydration and radiance. The effect reads as noticeably healthier skin, not a treated face. Improvement keeps developing over the weeks after treatment, with results that may last up to six months.
Related treatments at Dr Joney De Souza: Profhilo Structura, polynucleotides, skin boosters and fine lines.
Many patients notice visibly improved skin firmness, hydration and radiance following Profhilo treatment. In most cases, the skin appears more lifted and luminous within two to six weeks as collagen and elastin production increases.
Furthermore, with a second session four weeks after the first, the bio-remodelling effect deepens and patients can sustain improved skin quality over time. Individual results vary, and Dr De Souza will advise on realistic outcomes at your consultation.
Your practitioner injects Profhilo at specific bio-aesthetic points just beneath the skin, using a precise, methodical technique. Once placed, the high-concentration hyaluronic acid spreads across the tissue instead of staying in one spot, so hydration reaches a broad area from a handful of injections. As it disperses, it stimulates the fibroblasts that produce collagen and elastin, and firmness and elasticity build steadily over the following weeks.
Creams sit on the surface and can only do so much. Profhilo delivers its active ingredient straight to the deeper layers where the skin builds its quality, so most patients notice smoother, firmer, more radiant skin within two to four weeks.
Before anything begins, your practitioner takes time to understand your skin concerns and what you hope to achieve. They assess your skin to confirm Profhilo is the right choice and to map the correct injection points and depth for your skin type. Carried out by one of our doctors, Dr Joney De Souza or Dr Mattia Parducci. Your consultation is with Dr Joney De Souza or Dr Mattia Parducci. This step keeps every treatment personal to you rather than a fixed protocol.
The skin is cleansed thoroughly to lift away makeup, oils and skincare. A topical numbing cream is applied to the treatment area and left for roughly 20 minutes so the injections stay comfortable. Once the numbing has taken effect, most patients find the treatment entirely comfortable.
Your practitioner places Profhilo through a series of precise injections at set bio-aesthetic points. The technique lets the hyaluronic acid spread naturally and integrate evenly, rather than pooling in one area. How broadly and uniformly the improvement distributes comes down to this stage, so clinical precision here shapes the final result.
Straight after the injections, your practitioner reviews the treated area to confirm placement is right. Minor swelling, small bumps or tiny injection marks at this point are entirely normal and usually settle within a few hours to 24 hours. Your clinician runs through aftercare and answers any questions before you leave the clinic.
Over the days that follow, the skin responds as the hyaluronic acid disperses and begins stimulating collagen and elastin. Some patients notice early improvements in hydration within the first week. Fuller results usually develop over two to six weeks after the second session, as bio-remodelling progresses and the gains in firmness and radiance become clear.
Results from Profhilo may last up to six months, depending on your skin, lifestyle and skincare routine. Your practitioner will usually recommend a second session four weeks after the first, then maintenance around every six months to hold the hydration, firmness and skin quality you have gained. Many patients fold Profhilo into a regular skin programme alongside other treatments.
Every Profhilo treatment at Dr Joney De Souza Clinic starts with a personal consultation. Your practitioner takes time to understand your concerns and goals, with a close focus on firmness, hydration and overall skin quality, so the plan is built around your skin rather than a standard template.
Arrive with clean skin or minimal makeup. No special preparation is needed, though your clinician may suggest pausing retinoids or active acids for a few days beforehand. At the consultation your practitioner reviews your concerns in detail, walks you through the process and confirms the areas and bio-aesthetic points to be treated. It is a good moment to ask anything you are unsure about. Numbing cream goes on at this stage and takes around 20 minutes to work, so the appointment starts gently and at a measured pace.
Once the numbing has taken effect, your practitioner performs the injections with a fine needle, placing Profhilo at set bio-aesthetic points just beneath the skin. The technique is precise and methodical, letting the hyaluronic acid spread naturally across the tissue. Most patients find it entirely comfortable. The injection phase usually takes 15 to 20 minutes, and the full appointment, including consultation and numbing, is generally done within 45 minutes. You can return to your usual activities the same day.
Mild redness, small bumps or minor swelling may show at the injection sites afterwards. These are normal and typically settle within a few hours to 24 hours. Leave the area alone, keep skincare gentle and use SPF the next morning. Skip strenuous exercise for 24 hours and heat-based activities such as saunas or steam rooms for 48 hours. Results develop gradually, with the fullest improvement usually visible within two to six weeks after the second session as bio-remodelling progresses.
Plenty of clinics across London offer Profhilo. What sets this one apart is a genuinely doctor-led setting, where clinical assessment, technique and patient safety sit at the centre of every appointment. Dr Joney De Souza brings more than two decades of aesthetic medicine experience and a precise, considered approach to injectable work, and his philosophy shapes how the whole team treats.
My ‘less is more’ approach has become the mainstay of my practice and clients appreciate that they will have natural looking results.
Dr Joney De Souza, The Sybarite
That instinct for restraint matters with skin boosters, where the goal is your own skin looking its best, not a treated look. Speaking to Forbes on injectable skin boosters, Dr De Souza noted: Profhilo and Teosyal Redensity 1 are my go-to injectable skin boosters. Profhilo stimulates collagen and elastin production and improves skin quality, while Teosyal Redensity 1 is great for hydration and radiance.
(Forbes)
Profhilo is an injectable treatment, and its outcome rests on the precision of the technique and the choice of injection points. The approach here reflects the clinic’s commitment to clinical care: thorough assessment, careful placement and ongoing aftercare, so your result lands exactly as intended.
That is the thinking behind everything here, and by prompting the skin to build its own collagen and elastin, Profhilo works with your skin’s structure to support its quality and health for longer.
Profhilo pricing at Dr Joney De Souza Clinic reflects the full appointment, the doctor-led consultation, the personalised injection technique and the clinical aftercare, not just the product itself.
We offer Profhilo across the face, neck, décolletage, hands and body. After consultation your practitioner will confirm the most suitable areas and advise whether a single session or a full two-session initial course best fits your goals. Patients who complete both sessions four weeks apart tend to achieve the most comprehensive bio-remodelling result.
| Area | Associate (£) | x2 (£) | Dr Joney (£) | x2 (£) |
|---|---|---|---|---|
1 Area (Face OR Neck OR Décolletage) | 400 | 680 | 475 | 800 |
2 Areas | 680 | 1190 | 800 | 1400 |
3 Areas (Face, Neck & Décolletage) | 850 | 1400 | 1000 | 1650 |
Mouth & Lower Face | 275 | 445 | 325 | 525 |
Body 1 area | 400 | , | 475 | , |
Body 2 areas | 665 | , | 780 | , |
Body 3 areas | 850 | , | 1000 | , |
Profhilo and polynucleotides are both injectables built to improve skin quality rather than add volume, but they work through different mechanisms and suit different concerns. Profhilo uses a high concentration of pure hyaluronic acid to bio-remodel the skin, stimulating collagen and elastin while delivering deep hydration. It is particularly effective where the issue is skin laxity, lost firmness or crepey skin.
Polynucleotides work at a cellular level, prompting tissue regeneration and repair, which makes them well suited to skin ageing, fine lines or quality concerns that call for a regenerative approach. Here the choice between the two is guided by your individual skin assessment. Some patients do best with one alone, others with a combination as part of a longer-term skin-quality plan, and if loss of volume is also in the picture, your practitioner may bring other treatments into the discussion.
Profhilo is one of the most asked-about injectable skin treatments at Dr Joney De Souza Clinic. The questions below cover what patients raise most often at consultation, from how Profhilo works and what to expect, to who it suits and how it compares with other skin-quality treatments available in Marylebone, London.
Profhilo is a bio-remodelling injectable made from one of the highest concentrations of pure hyaluronic acid available. It is not a filler, so it does not add volume or change your shape. Instead it spreads through the skin to boost deep hydration and stimulate your own collagen and elastin. At Dr Joney De Souza Clinic in Marylebone, we use it for skin that looks dull, crepey or has lost firmness and bounce. The result is healthier, more supple, better-hydrated skin that still looks completely natural. It suits patients who want a skin-quality improvement rather than a change to their features.
Profhilo works across several areas where skin tends to lose firmness and hydration. The face is most common, but the neck, décolletage, hands, arms and knees respond well too. Each area uses precise injection points that let the product spread evenly and remodel the skin. The neck, hands and décolletage often show ageing early, so many patients treat these alongside the face for a balanced result. Your practitioner confirms the right areas for you at consultation.
The standard course is two sessions, spaced about four weeks apart, which gives the skin time to respond between treatments. After the initial course, most patients have a maintenance session roughly every six months to sustain results. Your practitioner may adjust this to suit your skin and goals, and will confirm your personal plan at the first appointment so you know what to expect.
Most patients begin to see better hydration, firmness and glow around four weeks after the second session, once the collagen-stimulating effect develops. Results typically last about six months, after which a maintenance session keeps the skin looking its best. Profhilo improves your skin’s own quality, so the change looks gradual and natural rather than sudden. Your individual response depends on your skin, age and lifestyle.
Profhilo uses a small number of precise injection points rather than treatment across the whole area, and the needle is very fine, so most patients find it quick and comfortable. You may notice small raised bumps at the points straight afterwards, but these usually settle within a few hours and almost always within 24 hours. Downtime is minimal and most patients carry on with their day. We suggest avoiding makeup, strenuous exercise and heat for the rest of the day.
Profhilo starts from £400 per session with an associate clinician and from £475 with Dr Joney De Souza, and a recommended course of two sessions is available at a reduced rate. Every price includes the doctor-led consultation, the treatment and clinical aftercare. The right plan depends on the areas treated, so your practitioner confirms your cost before treatment begins. You can see the full breakdown on our pricing page.
They address different things. Dermal fillers add volume and reshape features, while Profhilo improves overall skin quality without changing contour. Skin boosters also hydrate the skin, but Profhilo uses a higher concentration of hyaluronic acid that spreads more widely and stimulates collagen as well as hydration. Polynucleotides work differently again, triggering deeper cellular repair. If you are also concerned about loss of volume, that points more towards fillers, and your practitioner often combines treatments and advises on the right approach for your skin.
Yes. Profhilo combines well with most treatments because it improves skin quality rather than adding volume. Many patients pair it with anti-wrinkle injections or dermal fillers to address lines and volume at the same time as skin health, or with polynucleotides for deeper regeneration. Your practitioner sequences combined treatments sensibly within one plan. This layered approach often gives a more complete, natural-looking result than any single treatment on its own.
Profhilo has a strong safety record and uses pure hyaluronic acid that is biocompatible with the skin. Carried out by one of our doctors, Dr Joney De Souza or Dr Mattia Parducci. Your consultation is with Dr Joney De Souza or Dr Mattia Parducci. Your medical history and suitability are reviewed before treatment. Side effects are usually limited to small temporary bumps, mild redness or occasional bruising at the injection points. As an injectable medical treatment, it should always be performed by a qualified practitioner; you can read more via the MHRA.
No. Profhilo improves the quality and health of your skin rather than changing your shape, so you look fresher and more hydrated while staying completely yourself. It suits most adults seeking a skin-quality improvement, though your practitioner confirms suitability at consultation. To book, reach us by WhatsApp, phone or online. Dr Joney De Souza Clinic sits in Marylebone in central London, within easy reach of Bond Street, Baker Street and Marble Arch stations, and is convenient for patients across the West End and wider London.
Our patients return to us year after year for natural, balanced results. Every review reflects our commitment to precision, safety and a personalised approach to aesthetic care.
