Doctor-led PRF (Platelet-Rich Fibrin) at Dr Joney De Souza Clinic in Marylebone, London. Natural skin rejuvenation and hair restoration from £490. Book today.
Doctor-led PRF treatment in Marylebone, London. Platelet-Rich Fibrin injections for skin rejuvenation and hair restoration at Dr Joney De Souza Clinic.
If your skin has started to look tired, crepey or a little deflated, and you would rather rebuild it with your own biology than add a synthetic product, PRF is worth serious consideration. At Dr Joney De Souza Clinic in Marylebone, PRF draws on growth factors from your own blood to rejuvenate skin and support hair regrowth, and it tends to suit patients who are noticing:
PRF is at its best as a quality and regeneration treatment, refreshing tired, crepey skin gradually by drawing on your own biology, so results keep building naturally over the weeks that follow. If your priority is replacing lost volume or lifting more pronounced laxity, your practitioner can pair PRF with
dermal fillers or a tightening treatment so both concerns are covered together.
PRF stands for Platelet-Rich Fibrin, and it is the next generation of the well-known PRP treatment. It is created from a small sample of your own blood, spun gently at low speed with no anticoagulants. That slower spin keeps a natural fibrin matrix intact alongside your platelets and white blood cells, so the growth factors release slowly and steadily into the tissue over days and weeks rather than all at once.
At the Marylebone clinic, PRF is used to improve skin quality, encourage collagen production and support hair regrowth. It is the close cousin of
PRP treatment, and it builds on it: the gentler processing and richer fibrin scaffold give a more sustained, longer-lasting release of growth factors.
Related treatments at Dr Joney De Souza: PRP facial, PRP with SkinPen microneedling, polynucleotides and dark circles.
Many patients notice improved skin quality, texture and radiance following a course of PRF treatment. Results develop gradually as growth factors stimulate collagen production and tissue regeneration over the weeks following treatment.
Furthermore, patients using PRF for hair restoration often report reduced shedding and increased hair density after a course of sessions. Individual results vary, and Dr De Souza will advise on realistic outcomes at your consultation.
PRF puts your body’s own repair machinery to work. A small blood sample is drawn and spun in a centrifuge at low speed with no anticoagulants, which keeps a fibrin matrix intact alongside your platelets, white blood cells and growth factors. That concentrate is then injected into the skin or scalp, where the growth factors release slowly over days and weeks. The fibrin scaffold gives structural support while the tissue responds and repairs.
PRF works gradually rather than instantly, so improvements in skin quality and hair density build over weeks to months as collagen production ramps up and tissue regenerates. That slow build is the point, and it is why the finished result reads as refreshed rather than obviously treated.
Your practitioner starts by assessing your skin or scalp concerns in detail. This step confirms that PRF is the right treatment for your goals and pinpoints the areas and injection approach best suited to you. Every plan is built around your presentation rather than pulled from a fixed protocol.
A small sample of blood is drawn from your arm and placed in a centrifuge, then spun at low speed with no anticoagulants. This separates the red blood cells from the plasma while keeping a natural fibrin matrix rich in platelets and white blood cells. The PRF concentrate is then prepared for injection. Most patients find this step straightforward and much like a routine blood test.
The treatment area is thoroughly cleansed and, where appropriate, a topical anaesthetic is applied for comfort during injection. This matters particularly for the delicate under-eye area and for patients combining PRF with SkinPen microneedling. Numbing takes around 20 minutes to take full effect before the injection phase begins.
Your practitioner administers the PRF concentrate with a precise injection technique. Depending on the area and your goals, PRF may be delivered through multiple micro-injections into the superficial dermis, into the deep dermis, or into the scalp for hair restoration. How broadly and evenly the growth factors are distributed comes down to technique, so precision at this stage shapes the result directly.
Straight after injection, your practitioner reviews the treated area to confirm placement. Minor redness, small bumps or injection marks at this stage are entirely normal and usually settle within 24 to 48 hours. Your clinician confirms aftercare before you leave. Most patients return to their usual activities the same day or the next.
PRF works by stimulating your body’s own regenerative processes, so improvements arrive gradually rather than immediately. Early changes in skin hydration and quality may show within the first few weeks, while optimal results typically develop over two to six months as collagen production rises and tissue remodels. Most patients get the best outcome from a course of two treatments.
Every PRF treatment at Dr Joney De Souza Clinic starts with a personalised consultation. Your practitioner takes time to understand your skin concerns, your hair-loss history and your aesthetic goals, then builds the treatment plan around your specific presentation rather than a standard protocol. Carried out by one of our doctors, Dr Joney De Souza or Dr Mattia Parducci. Your consultation is with Dr Joney De Souza or Dr Mattia Parducci.
Arrive with clean skin and no makeup on the areas to be treated. No special preparation is needed, though your clinician may ask you to avoid blood-thinning medications or supplements such as aspirin and fish oil for a few days beforehand. At the consultation, your practitioner reviews your skin or hair concerns, talks you through the PRF process and confirms the areas and injection approach. Numbing cream is applied at this stage where appropriate and takes around 20 minutes to work.
Once the blood draw is done and the numbing has taken effect, your practitioner performs the injections with a fine needle. The technique is precise and adapted to the area, whether face, under-eyes, neck or scalp. Most patients find the treatment comfortable. The injection phase usually takes 15 to 20 minutes, and the full appointment, including blood draw and numbing, is generally finished within 60 minutes. You can return to your usual activities the same day or the next.
Mild redness, small bumps or minor swelling may be visible at the injection sites afterwards. These are entirely normal and typically settle within 24 to 48 hours. Avoid touching the treated area, apply gentle skincare and use SPF the following morning. Steer clear of strenuous exercise for 24 hours and heat-based activities such as saunas for 48 hours. PRF results build gradually, with meaningful improvement usually visible from four to six weeks as tissue regeneration progresses.
PRF is offered at plenty of clinics across London, so what sets one apart is the standard of hands behind the needle. At Dr Joney De Souza Clinic, every treatment is delivered in a doctor-led environment where clinical assessment, technique and patient safety come first. Dr De Souza brings over two decades of aesthetic medicine experience and a precise, considered approach to every injectable, an ethos he sums up simply.
My ‘less is more’ approach has become the mainstay of my practice and clients appreciate that they will have natural looking results. thesybarite.co
PRF is an injectable treatment, so its outcome rests on the precision of the technique and the choice of injection points. At Dr Joney De Souza Clinic that means thorough assessment, careful placement and proper aftercare support, so your result is exactly as intended.
PRF draws on your own blood to release growth factors slowly over time, so it supports the skin’s own capacity to rebuild its structure, an approach rooted in skin longevity rather than a quick fix.
PRF at Dr Joney De Souza Clinic is priced to reflect the doctor-led consultation, the personalised injection technique and the clinical aftercare that comes with every treatment. You are paying for the full appointment, not just the product.
PRF is offered for facial skin rejuvenation, the under-eye area, neck, décolletage and hair loss. After your consultation, your practitioner will confirm the most appropriate areas and advise whether a single session or a full course of two sessions best suits your goals. Patients who complete a full initial course tend to achieve the most comprehensive regenerative result.
| Treatment | Dr Joney (£) | Associate Clinician (£) |
|---|---|---|
PRF 1 Area (Face OR Neck OR Décolletage) | 575 | 490 |
PRF 2 Areas (Face OR Neck OR Décolletage) | 775 | 660 |
PRF for Hair Loss | 575 | 490 |
PRF and
PRP treatment are close relatives but distinct treatments. Both use your own blood to deliver growth factors that stimulate collagen production and tissue regeneration. The difference is in the processing: PRF is spun more slowly and without anticoagulants, which keeps a fibrin matrix intact and lets the growth factors release more slowly and steadily over time.
PRP uses a higher-speed spin and releases its growth factors more quickly but over a shorter window. At Dr Joney De Souza Clinic, the choice between the two is guided by your individual skin or hair concerns and your goals. Some patients also gain from pairing these regenerative treatments with polynucleotides or exosome treatment as part of a complete skin regeneration programme.
PRF is one of the most asked-about regenerative treatments at Dr Joney De Souza Clinic. The questions below cover the concerns patients raise most often at consultation, from how PRF works and what to expect, to who it suits and how it compares with other skin-quality and hair-restoration treatments available in Marylebone, London.
Our patients return to us year after year for natural, balanced results. Every review reflects our commitment to precision, safety and a personalised approach to aesthetic care.
