Profhilo Structura in Marylebone, London

Firm and define your lower face and jawline with Profhilo Structura at Dr Joney De Souza in Marylebone, London. Doctor-led, natural results from £900. Book today.

Profhilo Structura

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Procedure time
Around 45 minutes per session
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Back to work
Same day, downtime is minimal
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Anaesthetic
Topical numbing given as needed
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Results appear
Hydration within days; firming builds over weeks
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Results last
6 to 12 months, with maintenance every 6 to 9 months
Price From
£400
for a course of 2 sessions, 4 weeks apart

Who Is Profhilo Structura For?

If your jawline has started to soften and your lower face looks a little less defined than it once did, Profhilo Structura is built for exactly that moment. It works within the deeper structural layers of the skin, so it suits early to moderate laxity, the stage where definition first begins to fade but volume is still intact. You may recognise yourself in one or more of the concerns below.

  • Early to moderate skin laxity around the cheeks, jawline and lower face
  • Reduced firmness or thinning skin that has started to lose structure
  • Loss of definition along the jawline or hollowing at the temples
  • A preference for natural regeneration rather than filler-style volume
  • A wish to maintain skin strength proactively before laxity becomes pronounced

Profhilo Structura is at its best firming and supporting the lower face and restoring definition naturally. If your priority is heavier jowls, deep folds or lost volume, we will guide you to the right option at your consultation.

 

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What Is Profhilo Structura?

Profhilo Structura is an advanced injectable from the Profhilo family, developed specifically to firm and support the deeper structure of the skin. Standard Profhilo sits near the surface to hydrate and add glow. Structura is placed deeper, reinforcing the structural layers and superficial fat compartments that give the face its shape. As Dr Joney De Souza told Forbes, “The ones that contain solely hyaluronic acid in very high concentration (Profhilo)…” reward the skin with quality rather than bulk (Forbes).

Structura reinforces rather than fills, so the result looks like a naturally better-supported version of your own face. It never freezes movement or alters your expressions. Around 95 percent of patients notice lasting enhancement of the mid-face, which is why it is a favourite for restoring quiet definition without changing a patient’s features.

Related treatments at Dr Joney De Souza: standard Profhilo, our skin boosters, polynucleotides and a sagging jawline.

Profhilo Structura Before & After Results in Marylebone

Every result below is a real Dr Joney De Souza patient. Use the slider to see the change. Results vary from person to person.

Before
After
Before
After
Before
After

How Does Profhilo Structura Work?

Profhilo Structura delivers a highly concentrated hybrid hyaluronic acid, a substance your skin already produces naturally, into the deeper structural layers of the face. The formulation is denser and placed deeper than standard Profhilo, so it draws and holds water within the tissue while acting as a biostimulator that signals the skin to renew its own collagen, elastin and extracellular matrix. Put simply, it rebuilds the scaffolding that supports the lower face instead of laying filler-style volume on top.

Key Benefits

  • Firms and strengthens the deeper structure of the skin
  • Improves definition along the cheeks, jawline and temples
  • Stimulates your own collagen and elastin for lasting resilience
  • Restores density and support without adding unwanted volume
  • Delivers a natural result that never changes your features or expressions
  • Improves hydration and skin quality from within
  • Continues to improve for up to six months following your second session

Where in the skin does Structura sit?

Profhilo Structura is placed deeper than standard Profhilo, within the structural layers of the skin and the superficial fat compartments. These are the tissues that give the lower face its shape and support, so working at this depth reinforces the scaffolding rather than adding volume near the surface.

What is the hybrid hyaluronic acid?

The formulation is a highly concentrated hybrid hyaluronic acid, a substance your skin already produces naturally. It is denser than the version used in standard Profhilo, engineered to firm and support rather than simply hydrate the outer layers.

How does it stimulate collagen and elastin?

Once injected, the hybrid hyaluronic acid acts as a biostimulator that signals the skin to renew its own collagen, elastin and extracellular matrix. These fibres and support proteins naturally thin with age, so rebuilding them restores firmness and resilience where laxity first appears. It shares this collagen-stimulating principle with treatments like our polynucleotides.

Why does it firm rather than fill?

Structura is designed to strengthen the underlying tissue, not to enhance volume or change facial shape. The improvement comes from your own regenerated tissue, so the outcome looks like a naturally better-supported version of your face rather than a filled or altered one.

Does it affect facial movement?

No. Structura works structurally within the skin rather than on muscle, so it never freezes movement or alters your expressions. It works with your anatomy to improve support quietly and naturally.

Why do results keep improving after treatment?

The remodelling of collagen and elastin continues quietly in the weeks after each session. The change comes from your own regenerated tissue, so the firming and definition develop gradually and keep improving for up to six months following your second session.

Your Profhilo Structura Journey

From your first consultation to your follow-up review, your Profhilo Structura treatment at our Marylebone clinic is carried out by one of our doctors, Dr Joney De Souza or Dr Mattia Parducci. The treatment builds structural support gradually, so each stage is planned around your skin and your goals.

Before Your Treatment

Your practitioner assesses your skin’s firmness, density and early signs of laxity around the cheeks, jawline and lower face. Structura is deeper and more structural than standard Profhilo, so they explain exactly how it differs and whether it suits your goals. You leave the consultation with a clear, personalised plan before any treatment begins.

During Your Session

On the day, the treatment area is gently cleansed and a topical anaesthetic may be applied for comfort. Using precise injection techniques, your practitioner delivers the hybrid hyaluronic acid into the deeper structural layers at carefully mapped points. The appointment takes around 45 minutes, and most patients find it quick and comfortable.

After Your Treatment

You can return to most normal activities straight away, avoiding strenuous exercise, heat and pressure on the area for 24 to 48 hours. A second session is performed about four weeks later, when your practitioner reviews your progress and plans maintenance every six to nine months. You also receive clear written aftercare guidance to protect your result.

Why Dr Joney De Souza Clinic?

Structura works at a deeper structural level than standard Profhilo, so injection technique and anatomical judgement matter enormously. Every session here is carried out by one of our doctors, Dr Joney De Souza or Dr Mattia Parducci. Your consultation is with Dr Joney De Souza or Dr Mattia Parducci, at our Marylebone clinic near Harley Street.

“My ‘less is more’ approach has become the mainstay of my practice and clients appreciate that they will have natural looking results” Dr Joney De Souza, The Sybarite

  • Doctor-led throughout: a doctor assesses your skin and performs every Structura injection.
  • Lower-face and jawline expertise: Structura is placed to strengthen and define the areas where laxity shows first, without adding unwanted volume.
  • Natural, structural results: the treatment rebuilds support beneath the skin, so you look firmer and more defined rather than filled or altered.
  • Marylebone location: the clinic sits in the heart of Marylebone, close to Harley Street and easily reached from across central London.

A Medical Standard of Care

Profhilo Structura is a medical treatment, so every plan begins with a proper consultation to confirm your suitability and reduce risk before any injection. Your doctor carries out this assessment personally and provides clear written aftercare, so you are cared for to a genuine medical standard at every stage.

His thinking looks beyond the appointment to skin longevity, encouraging your own collagen to strengthen the deeper structure so the firmness and support you build hold up quietly for longer.

Profhilo Structura Pricing

Profhilo Structura starts from £400 at our Marylebone clinic, which covers a course of two sessions spaced four weeks apart. Every face is different, so the right plan depends on your skin, the areas being treated and how much support they need. The guide below helps you understand which approach may suit you.

Which Profhilo Structura Plan Is Right for You?

  • Standard two-session course: suits most patients and is the recommended starting point to achieve the full firming and lifting effect.
  • Course plus a third session: some patients with more advanced laxity or thinning skin benefit from an additional session for a stronger result.
  • Ongoing maintenance: a single session every six to nine months preserves the density and support you have built.

Pricing depends on your treatment areas and the plan you agree, so your exact investment and any recommended maintenance will be confirmed at your personal consultation.

TreatmentDr Joney (£)Associated Clinician (£)

Face

475

400

Combine with Standard Profhilo

Profhilo Structura and standard Profhilo are natural partners because they do complementary jobs. Structura is placed deeper to firm and support the lower face and jawline, while standard Profhilo spreads through the skin to boost overall hydration, radiance and glow across the wider face. Using them together treats both the structure and the surface, giving a more complete and balanced rejuvenation.

Structura strengthens the foundation first, so it can make the results of standard Profhilo look even more refined and better supported. Both treatments use hyaluronic acid and work with your own tissue rather than against your features, so they sit comfortably within one plan. Your practitioner will recommend the right sequence and combination for your skin at your consultation, and may also discuss where our wider range of skin boosters fits alongside them.

Explore Profhilo

Profhilo Structura: Frequently Asked Questions

Below are the questions patients most often ask about Profhilo Structura at our Marylebone clinic. Structura works differently from standard Profhilo and from dermal fillers, so understanding how it firms and supports the skin helps you decide whether it suits your goals.

How much does Profhilo Structura cost at Dr Joney De Souza in Marylebone?

Profhilo Structura starts from £900 at our Marylebone clinic, which covers a course of two sessions spaced four weeks apart. Every face is different, so your exact plan and any recommended maintenance will be confirmed at consultation. Most patients budget for the initial two-session course plus a maintenance session every six to nine months.

Is there any downtime after Profhilo Structura?

Downtime is minimal after Profhilo Structura. The product is injected at precise points, so you may notice small bumps, mild redness or slight swelling that typically settle within a few hours to 24 hours. Most patients return to normal activities straight away, avoiding strenuous exercise and heat for 24 to 48 hours.

When will I see results from Profhilo Structura?

Early improvements in hydration and skin texture may appear within days of your first session. The firming and lifting then develop gradually over several weeks as collagen and elastin production increases. Results continue to improve for up to six months following the second session and generally last between six and twelve months.

Is Profhilo Structura safe, and who performs it?

Profhilo Structura uses a well-established hybrid hyaluronic acid, a substance found naturally in the skin. The treatment is carried out by one of our doctors, Dr Joney De Souza or Dr Mattia Parducci, and your consultation is with Dr Joney De Souza or Dr Mattia Parducci. A medical consultation comes first, so your doctor confirms your suitability and reduces risk before any injection. Side effects are usually limited to temporary redness or small bumps at the injection points.

Will I look different after Profhilo Structura?

No. Structura enhances the firmness and quality of your skin without changing your facial features. It strengthens and supports rather than adds volume, so the result is a naturally refreshed, subtly lifted appearance that looks like you, only better supported. If you are more concerned about lost fullness in the cheeks or a loss of volume, we may suggest a different approach at consultation.

How is Profhilo Structura different from standard Profhilo?

Standard Profhilo spreads through the skin to boost overall hydration and glow, whereas Structura is placed deeper to firm and support the structure of the lower face and jawline. Think of Structura as structural reinforcement, and standard Profhilo as a hydration and radiance treatment.

How does Profhilo Structura compare with dermal fillers?

Unlike dermal fillers, Structura does not add volume or change your facial shape. Its purpose is to strengthen and remodel the underlying tissue, so the result is firmer, more elastic skin rather than augmentation. Fillers are chosen where genuine volume or projection is needed, while Structura is chosen to rebuild support and density.

Can Profhilo Structura be combined with other treatments?

Yes, Structura pairs well with several treatments to enhance overall rejuvenation. It strengthens the deeper layers, so your practitioner may combine it with standard Profhilo, dermal fillers, microneedling, mesotherapy or energy-based tightening for a fully balanced plan. They will recommend the right combination for your skin at your consultation.

4.9 ★★★★★

Read our reviews

Patients across London trust Dr Joney De Souza for natural, balanced results. Every review reflects our commitment to precision, safety and a personalised approach to aesthetic care at our Marylebone clinic.

I highly recommend Dr. Joney and his clinic. I have been his patient for many years and he is definitely one of the best. His work is natural and subtle, he always puts the patient’s interest first and will never try to upsell unnecessary treatments.

Had an excellent experience today getting the Profhilo treatment done by Dr. Joney De Souza. The entire team was so friendly, and prepped me about what I should expect during and after the treatment.

Dr Joney is the most wonderful Dr, kind and caring and highly experienced. I feel safe in his care and trust his opinion 100%.

Shelley Maxwell
Shelley Maxwell
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Kind words that made our day 🤍

We were so touched to receive this lovely feedback from a recent client following her PicoSure face treatment with Roma - this one’s for David, Roma, and Dr Joney.

“From the moment I arrived, David and Roma made me feel so welcome and completely at ease. Roma was caring, professional, and took the time to explain the treatment thoroughly, making sure I felt comfortable and reassured throughout. Even after just one session, my skin already feels smoother and looks much more refreshed.”

Moments like this are exactly why we do what we do. It’s not just about the results (although we’re so pleased with how her skin is already responding!), it’s about making every client feel genuinely cared for from the second they walk through the door.

Thank you to our amazing client for such kind words, and to David, Roma, and Dr Joney for the warmth and care you bring to every single appointment 🫶HydraFacial: the secret to that red-carpet glow ✨

Ever wondered what actually happens during a HydraFacial? Here’s a look inside the treatment, step by step, at Dr Joney De Souza.

It begins with a deep cleanse and exfoliation to clear away impurities and prepare the skin, followed by gentle extractions that refine congestion with complete comfort and precision. 

From there, targeted serums and boosters are infused into the skin, tailored entirely to your individual needs, before LED light therapy supports the skin’s long-term health and renewal. 

The treatment finishes with an antioxidant infusion, sealing in radiance for that lit-from-within finish.

This particular treatment was our Deluxe HydraFacial, though for those wanting to elevate the experience further, our Platinum HydraFacial also includes lymphatic drainage, perfect for extra de-puffing and detoxification alongside all the usual glow-boosting benefits.

The result is skin that looks cleansed, replenished, and effortlessly glowing, delivered with the precision and care that defines every treatment here.

📍 Marylebone, London | 020 7043 0748 📱Sculptra vs Juläine: which biostimulator is right for you? 💭

Both Sculptra and Juläine are poly-L-lactic acid (PLLA) biostimulators - meaning rather than simply adding volume, they work by encouraging your skin to produce its own natural collagen over time, for results that look and feel truly you.

Sculptra is the original PLLA injectable, with a long-established track record for stimulating collagen and improving skin structure and firmness gradually over several months, with results that can last up to two years.

Juläine is a newer generation PLLA treatment, using more uniform, highly purified microspheres engineered to mix more evenly, which can help reduce inflammation caused by treatment. Like Sculptra, results build gradually, with visible improvements from a few weeks in and full effects developing over a few months. 

Both are excellent options for restoring facial volume, improving skin quality, and softening lines. The right choice really depends on your skin, goals, and what your practitioner recommends for you.

Not sure which is best suited to your skin and goals? Get in touch with us today to book your consultation.

📍Marylebone, London | 020 7043 0748 📱Product Spotlight | Daily Power Defense ✨

ZO Skin Health’s Daily Power Defense is one of those products that quietly does a lot of the heavy lifting in a skincare routine, and it’s become a firm favourite of ours here at the clinic.

Formulated with Vitamins A and E, it helps protect the skin against environmental damage and free radicals, while supporting barrier restoration and long-lasting hydration.
Over time, this can mean fewer visible signs of premature ageing and a stronger, more resilient complexion.

It’s a lightweight daily step, but one that adds up - the kind of product that supports your skin quietly in the background, day after day.

If you’re curious whether it fits into your routine, drop us a DM, or ask at your next appointment 📅

How can you find us?

Our clinic is located in Marylebone, London, in the heart of one of Central London’s most prestigious and renowned medical districts. Perfectly positioned for convenience and discretion, we are easily accessible from across the capital and beyond.

We welcome patients from Mayfair, Harley Street, Marylebone, Knightsbridge, Belgravia, Chelsea, Kensington, Fitzrovia and St John’s Wood, as well as international patients visiting London for specialist treatment.

Our location benefits from excellent transport connections, with close proximity to major Underground stations, mainline rail links and direct access to Heathrow, Gatwick and London City airports. Several secure parking facilities and convenient chauffeur drop-off points are available nearby, ensuring a seamless and comfortable visit.

Whether you are travelling from elsewhere in London, across the UK or internationally, our clinic offers a calm, private and exclusive setting in one of the world’s leading medical destinations.

Opening hours
Monday
9 am to 6 pm
Tuesday
9 am to 6 pm
Wednesday
9 am to 6 pm
Thursday
9 am to 6 pm
Friday
9 am to 6 pm
Saturday
Closed
Sunday
Closed
Dr Joney De Souza
49 Blandford St, London W1U 7HH
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