Fine lines and wrinkles treatment in Marylebone, London. Anti-wrinkle injections, Profhilo, polynucleotides and CO2 laser, matched to your stage.
Dr Joney De Souza Clinic thinks of lines as a timeline. First come the expression lines, visible only when you frown, smile or raise your brows, printed and erased a thousand times a day by perfectly healthy muscles. Then, as collagen and hydration decline, the printing starts to stay: faint creases visible at rest, usually around the eyes, forehead and mouth. Left long enough in thinning, sun exposed skin, those creases etch into settled wrinkles and the surface itself turns crepey.
Where you are on that timeline decides everything. Moving lines want the muscle calmed. Settling lines want the skin rebuilt from within. Etched wrinkles and wrinkled, crepey texture want resurfacing. Sun exposure drives the whole progression harder than birthdays do, which is why the same age can wear such different faces.
Our approach softens what is there and slows what is coming, with expression always kept, because a face that cannot move reads older than any line. Injectables are performed by our doctors, and every plan pairs treatment with the daily SPF that protects it. That is the longevity minded way to wear a face: lines softened, character intact.
Lines sit on a timeline from movement to settled, and each stage responds to a different hand. Find the one that sounds like your mirror, then follow it through. Your doctor confirms the read at consultation, watching your face move and rest.
Frown, forehead, crow's feet
Lines that appear with expression and fade at rest are muscle driven and beautifully treatable. Conservative anti-wrinkle doses soften the overactive muscles so the printing eases, while your expressions stay warm and recognisably yours.
Faint, but there in the mirror
Creases beginning to show on a resting face mean the skin is losing the hydration and collagen that used to bounce them out. Profhilo floods the skin with hyaluronic acid and stimulates both, softening early set lines from within.
The surface itself has changed
Fine crosshatching and papery texture are skin quality stories rather than single lines. Polynucleotides support the skin’s own repair, rebuilding thickness and resilience so the surface holds light smoothly again over a short course.
Deep and present at rest
Wrinkles that have carved in over years want more than softening: CO2 laser resurfacing renews the creased surface and drives deep collagen repair, trading about a week of healing for the strongest single change on this page.
Volume is part of the story
Folds from the nose to the mouth and shadowed creases often trace back to deflating cheeks rather than the skin itself. Where volume leads, treating the line directly misses the cause, and our volume page covers that story properly.
Ahead of the curve
The honest prevention plan is smaller than the industry suggests: daily SPF, a retinoid, and conservative doses only where expression lines are starting to stay. We will happily tell you what not to have yet, which is its own kind of service.
Real results from our Marylebone clinic, photographed under consistent lighting. Every face lines differently, so treat these as an honest illustration of the natural, expression keeping style we work in rather than a promise of your own outcome.
Anti-wrinkle injections
Anti-wrinkle injections
CO2 laser resurfacing
| Compare | Anti-Wrinkle InjectionsLines that move | ProfhiloLines settling at rest | PolynucleotidesCrepey, tired texture | CO2 LaserEtched, settled wrinkles |
|---|---|---|---|---|
 |  |  |  | |
| Best for | Anti-Wrinkle Injections Frown, forehead and crow's feet lines in motion | Profhilo Early lines visible on a resting face | Polynucleotides Crepey, papery, slow to recover skin | CO2 Laser Deep set wrinkles and sun damaged texture |
| Typical course | Anti-Wrinkle Injections One appointment, refreshed every few months | Profhilo Two sessions, a month apart | Polynucleotides A course of three | CO2 Laser Usually a single session |
| Downtime | Anti-Wrinkle Injections None, tiny marks fade within hours | Profhilo Small bumps settling within a day or two | Polynucleotides Small bumps settling within a day or two | CO2 Laser Around a week of healing |
| Performed by | Anti-Wrinkle Injections Our doctors | Profhilo Our doctors | Polynucleotides Our doctors | CO2 Laser Experienced practitioners under medical oversight |
| Price from | Anti-Wrinkle Injections £190 | Profhilo £400 | Polynucleotides £410 | CO2 Laser £850 |
| View anti-wrinkle injections | View Profhilo | View polynucleotides | View CO2 laser |
Short clips from the treatment room at our Marylebone clinic, from injectables to CO2 laser.
Four routes matched to four stages of the same timeline: calm the movement, rebuild the skin, repair the texture, resurface the etched. Around them sit the supporting players: skin boosters for deep hydration, SkinPen microneedling for gradual collagen work, and Ultherapy where lines travel with laxity.
Calm the movement
Conservative doses soften the overactive muscles behind frown, forehead and crow’s feet lines, easing what is printed and slowing what is coming, with expression kept.
From £190, doctor performed.
Rebuild from within
Floods the skin with stabilised hyaluronic acid, boosting hydration and collagen so early set lines soften and the whole face regains bounce.
Two sessions, a month apart, doctor performed.
Repair the texture
Regenerative injections support the skin’s own repair, thickening crepey, papery texture and rebuilding resilience over a short course.
A course of three, doctor performed.
Resurface the etched
Fractional ablative resurfacing renews deeply lined, sun damaged skin and drives collagen repair beneath it, the strongest single move on this page.
Usually one session, about a week of healing.
Every plan at Dr Joney De Souza Clinic starts with reading your lines in motion and at rest, because the distinction decides the toolkit. Your doctor watches which lines print with expression and vanish, which linger, and which have etched in, then reads the skin quality and sun history around them. Lines that trace back to volume loss are named honestly, because treating the crease misses the cause.
Expression is treated as something to protect, not eliminate, and doses are planned accordingly. Plenty of first appointments end with less treatment than the person arrived expecting.
“My ‘less is more’ approach has become the mainstay of my practice and clients appreciate that they will have natural looking results.”
Dr Joney De Souza, speaking to The Sybarite
Here is what happens before, during and after treatment at our Marylebone clinic.
Your consultation maps your lines in motion and at rest, agrees the route and takes baseline photographs. For injectables we suggest avoiding alcohol for a couple of days beforehand; for laser, no sun exposure or self tan for two weeks.
Injectable appointments run fifteen to thirty minutes with numbing where wanted, a series of small, precise placements by your doctor. CO2 resurfacing is a longer, carefully numbed session delivered under medical oversight, planned around your diary’s quietest week.
Anti-wrinkle results build over one to two weeks, Profhilo and polynucleotides over the month as skin quality responds, and CO2 skin emerges from about a week of healing then keeps improving for months. Daily SPF protects all of it, and your review keeps the plan honest.
Genuinely, and prevention is the one place where home care can beat the clinic. Daily broad spectrum SPF slows the entire timeline more than any single treatment, a retinoid rebuilds collagen steadily, and vitamin C defends against the daily oxidative wear of city life. That routine, built properly with ZO Skin Health prescription skincare, is the foundation every treatment on this page stands on.
Where home care runs out of road is muscle and depth. No cream calms an overactive frown, rebuilds deep hydration or resurfaces an etched wrinkle, which is where the doctor performed routes take over.
What treatment will not do. We would rather say this plainly. Lines are softened and slowed, not deleted, and a face with no lines at all reads stranger than one with a few earned ones. Results are temporary and maintained rather than permanent, they vary between people, and we will not treat a face into stillness.
You may also want to read about related concerns we treat alongside lines, including loss of volume and lip lines.
The questions our Marylebone team hears most often about lines and wrinkles, from when to start to what treatment involves and costs. If yours is not here, message us on WhatsApp and one of the team will answer properly.
Stage, mostly. Fine lines are shallow and often only visible with expression or in certain light; wrinkles are the same creases after years of printing, etched deep enough to show on a resting face. The distinction matters because each stage responds to different treatment.
It follows the stage. Lines that move want conservative anti-wrinkle injections. Lines settling at rest want Profhilo, crepey texture wants polynucleotides, and etched wrinkles want CO2 resurfacing. Most faces sit between stages and blend two routes.
Not dosed the way we dose them. The frozen look is a dosing and placement failure, not a property of the treatment, and our doctors plan deliberately conservative doses that soften the print while your expressions stay warm and mobile. We would rather top up at review than freeze on day one.
When something bothers you, and not before. There is no medically correct age, and the honest prevention plan for most thirty somethings is SPF, a retinoid and patience, with conservative doses only where expression lines have started to stay. We will happily tell you what not to have yet.
An injectable that spreads stabilised hyaluronic acid through the skin, rebuilding hydration and stimulating collagen. It is the right tool when lines are beginning to show on a resting face and the skin has lost its bounce, softening the whole canvas rather than chasing single creases.
They work on the skin’s repair machinery rather than its water content, thickening and strengthening crepey, papery skin over a course of three sessions. Where Profhilo hydrates, polynucleotides regenerate, and crepey texture usually wants the latter first.
When wrinkles have etched in and the surface itself is sun damaged, because at that stage no injectable smooths the texture. One CO2 session achieves what years of gentler treatments cannot, at the honest cost of about a week of healing and diligent SPF afterwards.
Injectables are performed by our doctors, every time, and laser resurfacing is delivered by experienced practitioners under medical oversight. Dosing and placement judgement is what keeps line treatment natural, so it is never delegated to a non medical injector at our clinic.
Anti-wrinkle effects last a few months and are refreshed in rhythm. Profhilo and polynucleotide gains hold for six months or so after a course. Resurfaced skin is renewed for the long term, then simply ages at its own pace, protected by daily SPF.
Almost none for injectables: tiny marks or small bumps for a day or two at most. CO2 resurfacing is the exception, with about a week of healing planned around a quiet stretch of diary. Nothing on this page needs hiding beyond that.
Early ones, meaningfully: a consistent retinoid, vitamin C and daily SPF genuinely soften fine lines over months and slow new ones forming. What skincare cannot do is calm an overactive muscle or rebuild deep hydration, which is where lines that have settled need the clinic.
At our clinic, anti-wrinkle injections start from £190, Profhilo from £400, polynucleotides from £410 and CO2 resurfacing from £850. Our full price list has the detail.
Verified Google reviews from patients treated by our doctors at Dr Joney De Souza Clinic in Marylebone.
Had an excellent experience today getting the Profhilo treatment done by Dr. Joney De Souza. The entire team was so friendly, and prepped me about what I should expect during and after the treatment.
Had CO2 facial done about a month ago, my skin continues to look healthier, younger and less textured. The laser faded and continues to fade more stubborn acne scars.
All everyone wanted to do is make money selling me lasers and no one ever listened… until Dr Joney. He is the first doctor who truly understood my skin, listened to me, and gave me exactly what I needed with no pressure.
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