Is PicoSure Laser Safe? A London Doctor Reviews the Evidence

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Is PicoSure Laser Safe? A London Doctor Reviews the Evidence

At Dr Joney De Souza Skin & Laser in Marylebone, people considering pigmentation or tattoo treatment often ask: is PicoSure safe? It is a fair question, and the evidence is encouraging. PicoSure is a 755 nm picosecond laser, and studies report a strong safety profile, including in darker skin tones. Below, we review what the research shows, the side effects to expect, and how we keep treatment safe.

At Dr Joney De Souza, we use both PicoSure treatment heads. That includes the Focus lens, which targets skin rejuvenation, not only the head that treats pigmentation. Many clinics use the pigmentation head alone, because the Focus tip carries an extra cost to the clinic. We also include around 30 minutes of numbing and a full 45-minute treatment, rather than a rushed 15-minute session with no numbing. In practice, that means a more thorough and more comfortable treatment.

Key takeaways

  • Studies describe the 755 nm picosecond laser as safe and effective, with minimal side effects.
  • Most reactions are brief redness and swelling that settle within hours to a day.
  • Research in darker skin reports no permanent change in pigment when used correctly.
  • Its ultra-short pulses are gentler on the skin than older Q-switched lasers.

What Does the Clinical Evidence Say?

PicoSure has been studied in dermatology journals, including in skin of colour. A 2020 review in Dermatologic Surgery treated darker skin types for pigmentation. The authors found significant improvement and reported no permanent loss or gain of pigment. In short, the treatment was well tolerated.

Why Picosecond Pulses Are Gentler

The picosecond laser delivers energy in trillionths of a second. As a result, it shatters pigment with a photomechanical effect and less heat. Because there is less heat, the surrounding skin is better protected. For this reason, picosecond lasers carry a lower risk than older nanosecond devices. To explore the treatment, see our PicoSure laser page.

What Side Effects Can PicoSure Cause?

No treatment is entirely free of effects, so honesty matters. After PicoSure, most reactions are brief and mild. Typically, patients notice the following.

  • Redness and mild swelling, often settling within a day
  • Temporary darkening of pigment before it flakes away
  • A warm, tingling sensation during treatment
  • Rarely, short-lived lightening or darkening of the skin

Generally, these effects are short-lived. Importantly, studies in Asian skin report transient erythema that resolves quickly. This makes PicoSure a considered choice for pigmentation across a range of skin tones.

How We Keep PicoSure Safe at Our Clinic

Safety is about the operator as much as the laser. At our Marylebone clinic, several steps protect you.

  • A doctor-led consultation assesses your skin type and pigment first.
  • We tailor the settings to your skin, which lowers the pigmentation risk.
  • A patch test may be used before treating sensitive or darker skin.
  • Clear aftercare and daily sun protection support your result.

As a result, side effects stay minimal and brief. Moreover, every plan is matched to your skin and your goals.

Who Should Not Have PicoSure?

PicoSure is not suitable for everyone. We avoid treatment during pregnancy or breastfeeding. Equally, it is unsuitable over active infections, recent sun tan, or with certain photosensitive conditions. A consultation confirms whether it is right for you.

Book a Doctor-Led PicoSure Consultation in Marylebone

At Dr Joney De Souza Skin & Laser, every PicoSure treatment is doctor-led. To learn more, visit our PicoSure laser page and our prices list. Alternatively, book a consultation.

Clinical references

  1. Koh, Tan, Chua. Treatment of laser-responsive dermal pigmentary conditions in Type III-IV Asian skin with a 755-nm picosecond pulse duration laser: a retrospective review of its efficacy and safety. Dermatologic Surgery. 2020;46(11). PMC
  2. Hu S, Yang CS, Chang SL, Huang YL, Lin YF, Lee MC. Efficacy and safety of the picosecond 755-nm alexandrite laser for treatment of dermal pigmentation in Asians: a retrospective study. Lasers in Medical Science. 2020;35(6):1377-1383. PubMed
  3. Zhou et al. Safety and efficacy of a picosecond 755-nm alexandrite laser combined with topical tranexamic acid in the treatment of melasma. Journal of Cosmetic Dermatology. 2024. doi:10.1111/jocd.16432

Book PicoSure at Dr Joney De Souza

At Dr Joney De Souza Skin & Laser in Marylebone, every treatment is doctor-led and tailored to you. To discuss your goals and see current pricing, explore the treatment page or book a consultation with our team.

View PicoSure & prices
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PicoSure FAQs

Common questions our Marylebone team hears about this treatment.

Is PicoSure safe?

Peer-reviewed studies describe the 755 nm picosecond laser as safe and effective, with minimal, short-lived side effects when used by a trained clinician.

Is PicoSure safe for darker or Asian skin?

Yes. Studies in Type III to IV skin report good results with no permanent pigment change, as the settings are tailored to the skin.

What are the side effects of PicoSure?

Most patients notice only brief redness, mild swelling and temporary darkening of pigment that flakes away over a few days.

Does PicoSure hurt?

Treatment feels like a warm, tingling snap. A numbing cream can be used to keep you comfortable if needed.

How long do PicoSure side effects last?

Redness and swelling usually settle within hours to a day. Any pigment darkening flakes away over several days.

Is PicoSure safer than older lasers?

Its picosecond pulses deliver energy with less heat than older nanosecond lasers, which lowers the risk of pigment-related side effects.

Can PicoSure cause pigmentation problems?

Temporary changes can occur, but studies report no permanent pigment change when the laser is used correctly on suitable skin.

Who should not have PicoSure?

PicoSure is avoided during pregnancy or breastfeeding, over active infections, on freshly tanned skin, or with certain photosensitive conditions.

Is PicoSure FDA cleared?

PicoSure is a recognised, widely used picosecond laser platform. For safety, treatment should always be performed by a qualified clinician.

How can I reduce my risk with PicoSure?

Choose a doctor-led clinic, share your skin history, avoid sun before treatment, and follow the aftercare and SPF advice given.

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Profhilo vs Profhilo Structura - what is the difference? 👉

Both are injectable treatments containing hyaluronic acid. Both are produced by the same manufacturer. And both deliver beautiful, natural results. But they are not the same treatment, and understanding the difference is important when it comes to choosing the right one for your skin.

🫧 Profhilo
Profhilo is a skin booster. Its primary purpose is to deeply hydrate the skin, improve overall skin quality and stimulate the production of collagen and elastin. It spreads through the tissue to treat a wide area, leaving the skin looking more radiant, plump and youthful. It is suitable for a broad range of patients and is particularly effective for anyone experiencing dullness, dehydration or a general loss of skin glow.

🫧 Profhilo Structura
Profhilo Structura is specifically designed to address skin laxity and loss of firmness. It contains a higher concentration of high molecular weight hyaluronic acid, which works to remodel the deeper structural layers of the skin, restoring lift, firmness and definition in areas where the skin has begun to lose its architecture over time. It is particularly effective for the cheeks, jawline and neck.

Which one is right for you?
If your primary concern is skin quality, hydration and radiance, Profhilo is likely the right starting point. If you are noticing a loss of firmness, definition or lift, Profhilo Structura may be the more appropriate choice. For many patients, the two work beautifully together as part of a combined treatment plan.

The best way to find out is a thorough consultation with one of our medics 🤍Your guide to radiant summer skin ☀️

Summer is here, and your skin needs a little extra love. Swipe through for everything you need to know to keep your skin glowing all season long 👉

PicoSure targets pigmentation, sun damage and uneven skin tone at a cellular level - giving you a clearer, brighter complexion just in time for summer.

SPF 50, every single day. Non-negotiable. UV rays are present rain or shine, and no treatment or product can undo the damage of unprotected sun exposure. Apply every morning and reapply every two hours outdoors. 

Skin boosters deliver deep hydration from within - improving elasticity, smoothing texture and creating that natural, lit-from-within glow that no topical product can replicate. 

📍Marylebone, London | 020 7043 0748 📱A Wonderful Review for Roma ✨

At Dr. Joney De Souza Skin & Laser Clinic, we believe that exceptional results are achieved through expertise, personalised care, and a genuine commitment to every patient’s journey.

We are delighted to share this wonderful feedback for Roma, whose knowledge, skill, and thoughtful approach continue to make a lasting impact on those she treats.

Roma takes the time to understand each individual’s skin concerns and goals, creating tailored treatment plans that deliver beautiful, confidence-boosting results. Her warm and professional manner ensures every patient feels comfortable, informed, and in the safest of hands throughout their journey.

Roma, thank you for the dedication and care you bring to every appointment. We are incredibly proud to have you as part of the clinic.

And to our lovely client, Victoria, thank you for your kind words and for trusting us with your skin health. We are thrilled that you achieved such great results and look forward to welcoming you back soon 🫶If you read one thing today, please let it be this 🤍

July is UV Safety Awareness Month, and as a skin and laser clinic, there is genuinely nothing we feel more passionately about than protecting the skin you’re in.

UV radiation is the leading cause of skin cancer worldwide. UVA rays silently penetrate deep into the skin every single day - breaking down collagen, causing dark spots, wrinkles and long-term cellular damage - while UVB rays trigger the DNA mutations that lead to skin cancer. And they are both present even on overcast days in the UK.

The reality? Nearly 9 in 10 melanomas are preventable. That statistic is both sobering and empowering because it means the choices you make today genuinely matter.

Swipe through for everything you need to know about why UV protection is non-negotiable, what unprotected exposure is doing to your skin right now, and exactly how to protect yourself this summer and beyond...

SPF 50 every morning. A wide-brimmed hat. Shade between 10am and 4pm. UV-blocking sunglasses. Lightweight cover-up. These aren’t just suggestions, they’re the steps that protect your skin, your health and your future 🖤

#uvsafety #uvsafetyawarenessmonth #melanomaawarenessProduct Spotlight of the Month - July ☀️

Meet your summer non-negotiable: ZO Skin Health Daily Sheer Broad-Spectrum SPF 50.

With July bringing longer days, stronger UV rays and more time spent outdoors, there has never been a more important time to make sure your SPF is doing its job properly - and this one delivers on every level.

Unlike your average sunscreen, Daily Sheer protects against the full spectrum of sun damage - including blue light from your phone and screens, and the deeper rays that most SPFs simply don’t block.

It also delivers 12 hours of antioxidant defence against everyday environmental damage, going far beyond what a standard SPF can offer.

The formula is completely non-greasy, water resistant for up to 40 minutes, and dries down to a sheer finish that sits beautifully under makeup. No white cast. No heavy residue. Just effortless, daily protection.

Awarded the Seal of Recommendation by the Skin Cancer Foundation (USA) - because this isn’t just skincare, it’s skin health 🤍Have you ever truly seen what is happening beneath the surface of your skin? 🔍

At Dr Joney De Souza Skin & Laser, every skin journey begins with a VISIA Skin Analysis.

Before we recommend a treatment, we want to truly understand your skin at a level that goes far beyond what the naked-eye can see.

The VISIA is a state of the art imaging system that captures a comprehensive analysis of your skin across multiple key parameters - including spots, wrinkles, texture, pores, UV damage, brown spots, red areas and more. 

It reveals not only what is visible on the surface today, but also the underlying damage and concerns that have yet to fully emerge, giving us a complete and precise picture of your skin health.

This level of detail allows our clinical team to build a truly personalised treatment plan, targeting the root causes of your skin concerns rather than simply addressing what is visible on the surface. It takes the guesswork out of skincare entirely.

The VISIA also provides a benchmark against which we can measure your progress over time, so you can see exactly how your skin is responding to treatment and track your results with confidence.

Because great skin starts by understanding it 🤍

How can you find us?

Our clinic is located in Marylebone, London, in the heart of one of Central London’s most prestigious and renowned medical districts. Perfectly positioned for convenience and discretion, we are easily accessible from across the capital and beyond.

We welcome patients from Mayfair, Harley Street, Marylebone, Knightsbridge, Belgravia, Chelsea, Kensington, Fitzrovia and St John’s Wood, as well as international patients visiting London for specialist treatment.

Our location benefits from excellent transport connections, with close proximity to major Underground stations, mainline rail links and direct access to Heathrow, Gatwick and London City airports. Several secure parking facilities and convenient chauffeur drop-off points are available nearby, ensuring a seamless and comfortable visit.

Whether you are travelling from elsewhere in London, across the UK or internationally, our clinic offers a calm, private and exclusive setting in one of the world’s leading medical destinations.

Opening hours
Monday
9 am–6 pm
Tuesday
9 am–6 pm
Wednesday
9 am–6 pm
Thursday
9 am–6 pm
Friday
9 am–6 pm
Saturday
Closed
Sunday
Closed
Dr Joney De Souza
49 Blandford St, London W1U 7HH
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