Is PicoSure Laser Safe? A London Doctor Reviews the Evidence

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Is PicoSure Laser Safe? A London Doctor Reviews the Evidence

At Dr Joney De Souza Skin & Laser in Marylebone, people considering pigmentation or tattoo treatment often ask: is PicoSure safe? It is a fair question, and the evidence is encouraging. PicoSure is a 755 nm picosecond laser, and studies report a strong safety profile, including in darker skin tones. Below, we review what the research shows, the side effects to expect, and how we keep treatment safe.

At Dr Joney De Souza, we use both PicoSure treatment heads. That includes the Focus lens, which targets skin rejuvenation, not only the head that treats pigmentation. Many clinics use the pigmentation head alone, because the Focus tip carries an extra cost to the clinic. We also include around 30 minutes of numbing and a full 45-minute treatment, rather than a rushed 15-minute session with no numbing. In practice, that means a more thorough and more comfortable treatment.

Key takeaways

  • Studies describe the 755 nm picosecond laser as safe and effective, with minimal side effects.
  • Most reactions are brief redness and swelling that settle within hours to a day.
  • Research in darker skin reports no permanent change in pigment when used correctly.
  • Its ultra-short pulses are gentler on the skin than older Q-switched lasers.

What Does the Clinical Evidence Say?

PicoSure has been studied in dermatology journals, including in skin of colour. A 2020 review in Dermatologic Surgery treated darker skin types for pigmentation. The authors found significant improvement and reported no permanent loss or gain of pigment. In short, the treatment was well tolerated.

Why Picosecond Pulses Are Gentler

The picosecond laser delivers energy in trillionths of a second. As a result, it shatters pigment with a photomechanical effect and less heat. Because there is less heat, the surrounding skin is better protected. For this reason, picosecond lasers carry a lower risk than older nanosecond devices. To explore the treatment, see our PicoSure laser page.

What Side Effects Can PicoSure Cause?

No treatment is entirely free of effects, so honesty matters. After PicoSure, most reactions are brief and mild. Typically, patients notice the following.

  • Redness and mild swelling, often settling within a day
  • Temporary darkening of pigment before it flakes away
  • A warm, tingling sensation during treatment
  • Rarely, short-lived lightening or darkening of the skin

Generally, these effects are short-lived. Importantly, studies in Asian skin report transient erythema that resolves quickly. This makes PicoSure a considered choice for pigmentation across a range of skin tones.

How We Keep PicoSure Safe at Our Clinic

Safety is about the operator as much as the laser. At our Marylebone clinic, several steps protect you.

  • A doctor-led consultation assesses your skin type and pigment first.
  • We tailor the settings to your skin, which lowers the pigmentation risk.
  • A patch test may be used before treating sensitive or darker skin.
  • Clear aftercare and daily sun protection support your result.

As a result, side effects stay minimal and brief. Moreover, every plan is matched to your skin and your goals.

Who Should Not Have PicoSure?

PicoSure is not suitable for everyone. We avoid treatment during pregnancy or breastfeeding. Equally, it is unsuitable over active infections, recent sun tan, or with certain photosensitive conditions. A consultation confirms whether it is right for you.

Book a Doctor-Led PicoSure Consultation in Marylebone

At Dr Joney De Souza Skin & Laser, every PicoSure treatment is doctor-led. To learn more, visit our PicoSure laser page and our prices list. Alternatively, book a consultation.

Clinical references

  1. Koh, Tan, Chua. Treatment of laser-responsive dermal pigmentary conditions in Type III-IV Asian skin with a 755-nm picosecond pulse duration laser: a retrospective review of its efficacy and safety. Dermatologic Surgery. 2020;46(11). PMC
  2. Hu S, Yang CS, Chang SL, Huang YL, Lin YF, Lee MC. Efficacy and safety of the picosecond 755-nm alexandrite laser for treatment of dermal pigmentation in Asians: a retrospective study. Lasers in Medical Science. 2020;35(6):1377-1383. PubMed
  3. Zhou et al. Safety and efficacy of a picosecond 755-nm alexandrite laser combined with topical tranexamic acid in the treatment of melasma. Journal of Cosmetic Dermatology. 2024. doi:10.1111/jocd.16432

Book PicoSure at Dr Joney De Souza

At Dr Joney De Souza Skin & Laser in Marylebone, every treatment is doctor-led and tailored to you. To discuss your goals and see current pricing, explore the treatment page or book a consultation with our team.

View PicoSure & prices
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PicoSure FAQs

Common questions our Marylebone team hears about this treatment.

Is PicoSure safe?

Peer-reviewed studies describe the 755 nm picosecond laser as safe and effective, with minimal, short-lived side effects when used by a trained clinician.

Is PicoSure safe for darker or Asian skin?

Yes. Studies in Type III to IV skin report good results with no permanent pigment change, as the settings are tailored to the skin.

What are the side effects of PicoSure?

Most patients notice only brief redness, mild swelling and temporary darkening of pigment that flakes away over a few days.

Does PicoSure hurt?

Treatment feels like a warm, tingling snap. A numbing cream can be used to keep you comfortable if needed.

How long do PicoSure side effects last?

Redness and swelling usually settle within hours to a day. Any pigment darkening flakes away over several days.

Is PicoSure safer than older lasers?

Its picosecond pulses deliver energy with less heat than older nanosecond lasers, which lowers the risk of pigment-related side effects.

Can PicoSure cause pigmentation problems?

Temporary changes can occur, but studies report no permanent pigment change when the laser is used correctly on suitable skin.

Who should not have PicoSure?

PicoSure is avoided during pregnancy or breastfeeding, over active infections, on freshly tanned skin, or with certain photosensitive conditions.

Is PicoSure FDA cleared?

PicoSure is a recognised, widely used picosecond laser platform. For safety, treatment should always be performed by a qualified clinician.

How can I reduce my risk with PicoSure?

Choose a doctor-led clinic, share your skin history, avoid sun before treatment, and follow the aftercare and SPF advice given.

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Kind words that made our day 🤍

We were so touched to receive this lovely feedback from a recent client following her PicoSure face treatment with Roma - this one’s for David, Roma, and Dr Joney.

“From the moment I arrived, David and Roma made me feel so welcome and completely at ease. Roma was caring, professional, and took the time to explain the treatment thoroughly, making sure I felt comfortable and reassured throughout. Even after just one session, my skin already feels smoother and looks much more refreshed.”

Moments like this are exactly why we do what we do. It’s not just about the results (although we’re so pleased with how her skin is already responding!), it’s about making every client feel genuinely cared for from the second they walk through the door.

Thank you to our amazing client for such kind words, and to David, Roma, and Dr Joney for the warmth and care you bring to every single appointment 🫶HydraFacial: the secret to that red-carpet glow ✨

Ever wondered what actually happens during a HydraFacial? Here’s a look inside the treatment, step by step, at Dr Joney De Souza.

It begins with a deep cleanse and exfoliation to clear away impurities and prepare the skin, followed by gentle extractions that refine congestion with complete comfort and precision. 

From there, targeted serums and boosters are infused into the skin, tailored entirely to your individual needs, before LED light therapy supports the skin’s long-term health and renewal. 

The treatment finishes with an antioxidant infusion, sealing in radiance for that lit-from-within finish.

This particular treatment was our Deluxe HydraFacial, though for those wanting to elevate the experience further, our Platinum HydraFacial also includes lymphatic drainage, perfect for extra de-puffing and detoxification alongside all the usual glow-boosting benefits.

The result is skin that looks cleansed, replenished, and effortlessly glowing, delivered with the precision and care that defines every treatment here.

📍 Marylebone, London | 020 7043 0748 📱Sculptra vs Juläine: which biostimulator is right for you? 💭

Both Sculptra and Juläine are poly-L-lactic acid (PLLA) biostimulators - meaning rather than simply adding volume, they work by encouraging your skin to produce its own natural collagen over time, for results that look and feel truly you.

Sculptra is the original PLLA injectable, with a long-established track record for stimulating collagen and improving skin structure and firmness gradually over several months, with results that can last up to two years.

Juläine is a newer generation PLLA treatment, using more uniform, highly purified microspheres engineered to mix more evenly, which can help reduce inflammation caused by treatment. Like Sculptra, results build gradually, with visible improvements from a few weeks in and full effects developing over a few months. 

Both are excellent options for restoring facial volume, improving skin quality, and softening lines. The right choice really depends on your skin, goals, and what your practitioner recommends for you.

Not sure which is best suited to your skin and goals? Get in touch with us today to book your consultation.

📍Marylebone, London | 020 7043 0748 📱Product Spotlight | Daily Power Defense ✨

ZO Skin Health’s Daily Power Defense is one of those products that quietly does a lot of the heavy lifting in a skincare routine, and it’s become a firm favourite of ours here at the clinic.

Formulated with Vitamins A and E, it helps protect the skin against environmental damage and free radicals, while supporting barrier restoration and long-lasting hydration.
Over time, this can mean fewer visible signs of premature ageing and a stronger, more resilient complexion.

It’s a lightweight daily step, but one that adds up - the kind of product that supports your skin quietly in the background, day after day.

If you’re curious whether it fits into your routine, drop us a DM, or ask at your next appointment 📅

How can you find us?

Our clinic is located in Marylebone, London, in the heart of one of Central London’s most prestigious and renowned medical districts. Perfectly positioned for convenience and discretion, we are easily accessible from across the capital and beyond.

We welcome patients from Mayfair, Harley Street, Marylebone, Knightsbridge, Belgravia, Chelsea, Kensington, Fitzrovia and St John’s Wood, as well as international patients visiting London for specialist treatment.

Our location benefits from excellent transport connections, with close proximity to major Underground stations, mainline rail links and direct access to Heathrow, Gatwick and London City airports. Several secure parking facilities and convenient chauffeur drop-off points are available nearby, ensuring a seamless and comfortable visit.

Whether you are travelling from elsewhere in London, across the UK or internationally, our clinic offers a calm, private and exclusive setting in one of the world’s leading medical destinations.

Opening hours
Monday
9 am to 6 pm
Tuesday
9 am to 6 pm
Wednesday
9 am to 6 pm
Thursday
9 am to 6 pm
Friday
9 am to 6 pm
Saturday
Closed
Sunday
Closed
Dr Joney De Souza
49 Blandford St, London W1U 7HH
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