Compare PRP and PRF treatments at Dr Joney De Souza in Marylebone: facial rejuvenation, hair loss and combinations. Doctor-led, from £490.
You may have reached the point where good skincare is no longer enough, and you want a genuine improvement in skin or scalp quality without adding fillers or synthetic material. That is exactly what the platelet-based family suits. It is a strong fit if you are dealing with dull or crepey skin, delicate under-eye concerns, early to moderate hair thinning, or mild acne scarring, and you would rather work with your own biology than introduce a foreign substance. These treatments will not add volume or lift the way dermal fillers do, and they are not an overnight fix, so if you want an instant change for a single event they are the wrong starting point. They reward patience, because the improvement builds as your own tissue regenerates.
Dr Joney De Souza Clinic offers a full family of platelet-based regenerative treatments from the Marylebone clinic in London, each drawn from a small sample of your own blood. PRP and PRF are not interchangeable, and the right choice depends on what you want to treat and how you want your results to develop. Standard PRP delivers an active plasma, while slower-spun PRF preserves a natural fibrin matrix for a more sustained release. Use the comparison below to see how a PRP facial, PRF, PRP for hair loss, and PRP with SkinPen microneedling differ across what they treat, what is injected, sessions, downtime, and price.
Related treatments at Dr Joney De Souza: PRF, PRP for hair loss and PRP with SkinPen.
| Compare PRP & PRF treatments | PRP FacialPlatelet-rich plasma | PRFPlatelet-rich fibrin | PRP for Hair LossScalp restoration | PRP + SkinPenCombination |
|---|---|---|---|---|
 |  |  | ||
| Best for | PRP Facial Overall skin quality, texture, radiance and fine lines | PRF Delicate under-eye skin, dark circles and sensitive skin | PRP for Hair Loss Early to moderate scalp thinning and shedding | PRP + SkinPen Acne scarring, uneven texture and enlarged pores |
| What is injected | PRP Facial Concentrated platelet-rich plasma from your own blood | PRF Platelet-rich fibrin with a fibrin matrix and no anticoagulant | PRP for Hair Loss Platelet-rich plasma injected across the scalp | PRP + SkinPen PRP applied and injected after SkinPen microneedling |
| How it works | PRP Facial Growth factors stimulate collagen and improve microcirculation | PRF Fibrin scaffold releases growth factors slowly and sustainably | PRP for Hair Loss Growth factors reactivate dormant follicles into the growth phase | PRP + SkinPen Micro-channels let PRP reach deeper to amplify collagen repair |
| Sessions | PRP Facial Course of 2 to 3, spaced 4 to 6 weeks apart | PRF Course of 2, spaced 6 to 8 weeks apart | PRP for Hair Loss Course of 3, spaced 4 to 6 weeks apart | PRP + SkinPen Course of 3, spaced 4 to 6 weeks apart |
| Downtime | PRP Facial Mild redness or swelling for 24 to 48 hours | PRF About 2 days of mild redness | PRP for Hair Loss Mild scalp redness for about 24 hours | PRP + SkinPen Mild redness for 1 to 3 days |
| Price from | PRP Facial £490 | PRF £550 | PRP for Hair Loss £490 | PRP + SkinPen £490 |
| View PRP facial | View PRF | View PRP hair loss | View PRP + SkinPen |
Every platelet-based treatment here is planned and delivered as a medical procedure, not a routine add-on. These treatments use your own blood, so precision in preparation and placement matters as much as the injection itself. Carried out by one of our doctors, Dr Joney De Souza or Dr Mattia Parducci. Your consultation is with Dr Joney De Souza or Dr Mattia Parducci.
My ‘less is more’ approach has become the mainstay of my practice and clients appreciate that they will have natural looking results. Dr Joney De Souza, The Sybarite
By drawing on your own platelets and fibrin to support the skin’s natural collagen response, this is regenerative care that works with your biology to protect skin quality and health over time.
Whichever treatment you choose, the pathway follows the same careful stages, from your first consultation through to your review. Results develop gradually as collagen rebuilds, so your practitioner sets clear expectations at every step and you always know what to expect from your course.
Your practitioner reviews your skin or scalp condition, medical history and goals to confirm suitability and recommend whether PRP, PRF or a combination is right for you. You will also get clear guidance on the number of sessions your concern is likely to need.
You will be asked to avoid blood-thinning medication, supplements and alcohol in the days before your appointment where medically appropriate. Staying well hydrated helps ensure a good quality blood draw on the day.
Using a small sample of your own blood, the team draws, centrifuges and prepares your plasma or fibrin, then applies a topical numbing cream before your practitioner injects the treated area. Most patients describe the sensation as mild pressure rather than sharp pain.
Growth factors activate collagen-producing cells over the following weeks, gradually improving skin firmness, texture and radiance, or reactivating hair follicles. The full benefit of a course typically becomes visible around the three-month mark.
Once your session is complete, you avoid strenuous exercise, saunas and direct sun exposure for a short period while the skin or scalp settles. Your practitioner then reviews your progress and confirms any maintenance you may need.
Book a consultation with Dr Joney De Souza in Marylebone, and we will assess your skin or scalp and recommend the regenerative treatment best suited to your goals.
Below are the questions patients most often ask about our platelet-based regenerative treatments in London. If your question is not covered here, the team is happy to help at consultation.
At Dr Joney De Souza in Marylebone, PRP starts from £490 for one area in a single session, and PRP for hair loss also starts from £490 per session. PRF starts from £550. Final pricing depends on the number of areas treated and whether any additional treatment is included, which your practitioner confirms at consultation.
PRF is a newer generation of platelet preparation. It is spun at a lower centrifuge speed and without anticoagulant, so it preserves a natural fibrin matrix alongside the platelets and white blood cells. That fibrin matrix releases growth factors slowly and sustainably rather than all at once, which can give a longer-lasting improvement in skin quality compared with standard PRP.
A standard PRP facial suits overall skin quality, texture and radiance, while PRF suits delicate areas such as under the eyes and patients with sensitive skin who want a slower, sustained release. PRP for hair loss targets scalp thinning, and PRP with SkinPen is chosen for acne scarring and texture. If your main concern is loss of volume rather than skin quality, dermal fillers may suit you better, and your practitioner will recommend the right option after assessing you at consultation.
Downtime is minimal across all four treatments. Mild redness or swelling is common for the first 24 to 48 hours, and PRF settles in around two days. PRP with SkinPen can leave mild redness for one to three days. Most patients return to normal activities quickly while the regenerative process develops underneath.
Most patients find these treatments comfortable. A topical numbing cream is applied before injections, so the sensation is usually described as mild pressure rather than sharp pain. The initial blood draw feels the same as a routine blood test.
These are among the safest treatments in aesthetic medicine, because they use nothing but your own blood, with no synthetic material and no risk of allergic reaction. They work through your own biology, so PRP and PRF are suitable for all skin types and tones, subject to a medical assessment.
It depends on the treatment and your concern. A PRP facial course is usually two to three sessions spaced four to six weeks apart, PRF is a course of two spaced six to eight weeks apart, and both PRP for hair loss and PRP with SkinPen are typically a course of three. Your practitioner confirms your plan at consultation.
Between them, these treatments address skin texture, radiance, fine lines and mild acne scarring, delicate under-eye concerns such as dark circles and crepey skin, and early to moderate hair loss. They improve the underlying quality and regenerative capacity of the tissue rather than adding volume the way dermal fillers do.
Carried out by one of our doctors, Dr Joney De Souza or Dr Mattia Parducci. Your consultation is with Dr Joney De Souza or Dr Mattia Parducci. Treatment is never delegated to a non-medical practitioner, and CE-certified equipment is used at every session.
Yes. Dr Joney De Souza Clinic treats patients from across London and beyond at the Marylebone clinic, which is within easy reach of Bond Street, Baker Street and Marble Arch tube stations. A course involves several visits, so many patients travel in specifically for their regenerative treatment plan.
Patients return to Dr Joney De Souza year after year for doctor-led, natural results. Dr Joney De Souza Clinic holds a 4.9-star rating from over 270 verified Google reviews, including PRP and hair loss treatments in London.
I highly recommend Dr. Joney and his clinic. I have been his patient for many years and he is definitely one of the best. His work is natural and subtle, he always puts the patient’s interest first and will never try to upsell unnecessary treatments.
Had an excellent experience today getting the Profhilo treatment done by Dr. Joney De Souza. The entire team was so friendly, and prepped me about what I should expect during and after the treatment.
Dr Joney is the most wonderful Dr, kind and caring and highly experienced. I feel safe in his care and trust his opinion 100%.
