Treatments that support your skin’s own repair, for healthy skin that ages well.
Dr Joney De Souza is a doctor-led skin and laser clinic in Marylebone, and regenerative aesthetics sits at the heart of how we think about skin. Rather than only adding volume or softening a single line, this approach works with your skin’s own biology, supporting collagen, repair and overall skin quality so the tissue behaves in a healthier, more resilient way. The aim is skin that looks like itself, only better cared for.
There is a real shift happening in aesthetics, away from reactive correction and towards something closer to skin longevity: treating skin as living tissue you can nurture, protect and keep in good condition over the years. Regenerative treatments encourage the skin to rebuild its own structure gradually, which is why they suit people who want to look after their skin thoughtfully rather than wait for concerns to appear. Results build over time and vary from person to person, and our doctors will always be honest with you about what to expect.
| Treatment | SculptraStructural biostimulator | ProfhiloHydrating bioremodeller | PolynucleotidesRegenerative skin conditioner |
|---|---|---|---|
 |  |  | |
| What it is | Sculptra Injectable that stimulates the skin's own collagen | Profhilo Stabilised hyaluronic acid that remodels the skin | Polynucleotides Purified polymers that support skin repair |
| Best for | Sculptra Restoring volume and facial structure over time | Profhilo Dull, crepey or dehydrated skin quality | Polynucleotides Fragile skin, under eyes and fine texture |
| Results appear | Sculptra Gradually over several weeks, results vary | Profhilo Gradually from around four weeks, results vary | Polynucleotides Gradually over several weeks, results vary |
| Typical longevity | Sculptra Around 18 to 24 months, varies | Profhilo Around 6 to 9 months, varies | Polynucleotides Around 6 to 12 months, varies |
| Sessions | Sculptra Usually 2 to 3 sessions | Profhilo Typically 2 sessions, four weeks apart | Polynucleotides Usually 2 to 3 sessions |
| Downtime | Sculptra Minimal, mild swelling or bruising possible | Profhilo Minimal, small bumps settle within hours | Polynucleotides Minimal, brief redness at injection points |
| Explore Sculptra | Explore Profhilo | Explore Polynucleotides |
| Treatment | PRPPlatelet-rich plasma | PRFPlatelet-rich fibrin | Exosome TherapyCellular signalling boost |
|---|---|---|---|
 |  |  | |
| What it is | PRP Concentrated platelets drawn from your own blood | PRF A richer fibrin concentrate from your own blood | Exosome Therapy Signalling exosomes applied during microneedling |
| Best for | PRP Dull skin, texture and early skin quality | PRF Under eyes and areas needing sustained support | Exosome Therapy Boosting recovery and skin quality alongside SkinPen |
| Results appear | PRP Gradually over several weeks, results vary | PRF Gradually over several weeks, results vary | Exosome Therapy Gradually over several weeks, results vary |
| Typical longevity | PRP Around 9 to 12 months, varies | PRF Around 12 to 18 months, varies | Exosome Therapy Around 6 to 12 months, varies |
| Sessions | PRP Usually 3 sessions, spaced monthly | PRF Usually 2 to 3 sessions | Exosome Therapy Applied within a microneedling course |
| Downtime | PRP Minimal, redness settles within a day | PRF Minimal, mild swelling possible briefly | Exosome Therapy Follows microneedling, redness for a day |
| Explore PRP | Explore PRF | Explore Exosome Therapy |
| Treatment | SkinPen MicroneedlingCollagen-inducing microneedling | SkinviveInjectable skin hydration | MesotherapyMicro-nutrient infusion |
|---|---|---|---|
 |  |  | |
| What it is | SkinPen Microneedling Fine needles that stimulate the skin's own collagen | Skinvive Microdroplet hyaluronic acid that hydrates the skin | Mesotherapy Tailored vitamins and nutrients delivered into skin |
| Best for | SkinPen Microneedling Texture, scarring, pores and overall renewal | Skinvive Smoothness, glow and lasting hydration on cheeks | Mesotherapy Dull, tired skin needing a quality boost |
| Results appear | SkinPen Microneedling Gradually over several weeks, results vary | Skinvive Gradually within a few weeks, results vary | Mesotherapy Gradually over several weeks, results vary |
| Typical longevity | SkinPen Microneedling Around 6 to 12 months, varies | Skinvive Around 6 to 9 months, varies | Mesotherapy Around 4 to 6 months, varies |
| Sessions | SkinPen Microneedling Usually 3 to 4 sessions | Skinvive One session, top-ups as needed | Mesotherapy Usually 3 to 5 sessions |
| Downtime | SkinPen Microneedling Redness for one to two days | Skinvive Minimal, small bumps settle quickly | Mesotherapy Minimal, brief redness at entry points |
| Explore SkinPen Microneedling | Explore Skinvive | Explore Mesotherapy |
| Treatment | Morpheus8Radiofrequency microneedling | UltherapyFocused ultrasound lifting | Fractional Laser 1540Non-ablative fractional laser |
|---|---|---|---|
 |  |  | |
| What it is | Morpheus8 Microneedling with radiofrequency energy for remodelling | Ultherapy Focused ultrasound reaching the deeper support layers | Fractional Laser 1540 Palomar Icon 1540nm non-ablative fractional laser |
| Best for | Morpheus8 Laxity, jawline and deeper skin structure | Ultherapy Gentle lifting of brow, jawline and neck | Fractional Laser 1540 Texture, fine lines, scars and skin quality |
| Results appear | Morpheus8 Gradually over three to six months, results vary | Ultherapy Gradually over two to three months, results vary | Fractional Laser 1540 Gradually over several weeks, results vary |
| Typical longevity | Morpheus8 Around 12 to 18 months, varies | Ultherapy Around 12 to 18 months, varies | Fractional Laser 1540 Around 12 to 18 months, varies |
| Sessions | Morpheus8 Usually 3 sessions, monthly | Ultherapy Usually a single session | Fractional Laser 1540 Usually 3 to 4 sessions |
| Downtime | Morpheus8 Redness and swelling for a few days | Ultherapy Minimal, mild tenderness possible | Fractional Laser 1540 Redness for two to three days |
| Explore Morpheus8 | Explore Ultherapy | Explore Fractional Laser 1540 |
Regenerative work rewards patience and good judgement, and that is exactly how our clinic practises. Every plan is built around your skin’s structure and long-term health, not a quick fix.
Good regenerative results come from a considered plan rather than a single appointment. Here is how the process usually unfolds with us.
The best way to understand what your skin needs is a face-to-face conversation. Book a consultation with Dr Joney De Souza or Dr Mattia Parducci, and we will assess your skin, talk through your goals and design a regenerative plan that suits you and how you want to look after your skin over the years.
Below are the questions patients most often ask Dr Joney De Souza about regenerative treatments. If your question is not covered here, the team in Marylebone is happy to help.
Regenerative aesthetics is an approach that supports your skin’s own repair and renewal rather than simply covering or filling a concern. The treatments encourage the skin to produce its own collagen and improve its quality and structure, so the improvement comes from within the tissue itself. It suits people who want healthier, better-conditioned skin and are happy for results to build gradually over time.
Fillers add volume to reshape or plump an area, and muscle-relaxing injections soften the movement that creates expression lines. Both have their place. Regenerative treatments work differently: instead of adding a substance to change a shape, they prompt your skin to rebuild its own collagen and improve its overall quality. Many patients combine the two philosophies, and our doctors will explain honestly where each one helps.
Several of our treatments fall under this umbrella. Collagen-stimulating options include Sculptra and polynucleotides, which encourage the skin to rebuild its own support over time. Skin-quality and hydration treatments such as Profhilo and microneedling with SkinPen improve the condition and resilience of the skin. Your consultation will identify which of these suit your skin.
Regenerative treatments work gradually, which is part of what makes the results look natural. They rely on your skin producing its own collagen over weeks, so most people notice changes over the following one to three months, with improvement often continuing after that. The exact timeline varies from person to person and depends on the treatment, your skin and how many sessions you have.
Regenerative aesthetics can be preventative as well as corrective. Starting to support your skin’s collagen and quality earlier can help you maintain good skin health for longer, which is why some people begin in their late twenties or thirties, while others start later. There is no single right age. What matters is your skin’s current condition and your goals, which we will assess together.
Your plan is designed and overseen by our doctors, Dr Joney De Souza and Dr Mattia Parducci, who lead consultations and injectable treatments such as Sculptra and PRP. Energy and laser-based treatments are carried out by Roma, our laser and skin specialist. Everything is delivered within a doctor-led clinic in Marylebone.
Patients rate Dr Joney De Souza 4.9 out of 5 across hundreds of Google reviews. Read what they say about their treatments at the Marylebone clinic.
I highly recommend Dr. Joney and his clinic. I have been his patient for many years and he is definitely one of the best. His work is natural and subtle, he always puts the patient’s interest first and will never try to upsell unnecessary treatments.
Had an excellent experience today getting a regenerative treatment done by Dr. Joney De Souza. The entire team was so friendly, and prepped me about what I should expect during and after the treatment.
Dr Joney is the most wonderful Dr, kind and caring and highly experienced. I feel safe in his care and trust his opinion 100%.
