
Firm and define your lower face and jawline with Profhilo Structura at Dr Joney De Souza in Marylebone, London. Doctor-led, natural results from £900. Book today.
If your jawline has started to soften and your lower face looks a little less defined than it once did, Profhilo Structura is built for exactly that moment. It works within the deeper structural layers of the skin, so it suits early to moderate laxity, the stage where definition first begins to fade but volume is still intact. You may recognise yourself in one or more of the concerns below.
Profhilo Structura is at its best firming and supporting the lower face and restoring definition naturally. If your priority is heavier jowls, deep folds or lost volume, we will guide you to the right option at your consultation.

Profhilo Structura is an advanced injectable from the Profhilo family, developed specifically to firm and support the deeper structure of the skin. Standard Profhilo sits near the surface to hydrate and add glow. Structura is placed deeper, reinforcing the structural layers and superficial fat compartments that give the face its shape. As Dr Joney De Souza told Forbes, “The ones that contain solely hyaluronic acid in very high concentration (Profhilo)…” reward the skin with quality rather than bulk (Forbes).
Structura reinforces rather than fills, so the result looks like a naturally better-supported version of your own face. It never freezes movement or alters your expressions. Around 95 percent of patients notice lasting enhancement of the mid-face, which is why it is a favourite for restoring quiet definition without changing a patient’s features.
Related treatments at Dr Joney De Souza: standard Profhilo, our skin boosters, polynucleotides and a sagging jawline.

Profhilo Structura delivers a highly concentrated hybrid hyaluronic acid, a substance your skin already produces naturally, into the deeper structural layers of the face. The formulation is denser and placed deeper than standard Profhilo, so it draws and holds water within the tissue while acting as a biostimulator that signals the skin to renew its own collagen, elastin and extracellular matrix. Put simply, it rebuilds the scaffolding that supports the lower face instead of laying filler-style volume on top.
Profhilo Structura is placed deeper than standard Profhilo, within the structural layers of the skin and the superficial fat compartments. These are the tissues that give the lower face its shape and support, so working at this depth reinforces the scaffolding rather than adding volume near the surface.
The formulation is a highly concentrated hybrid hyaluronic acid, a substance your skin already produces naturally. It is denser than the version used in standard Profhilo, engineered to firm and support rather than simply hydrate the outer layers.
Once injected, the hybrid hyaluronic acid acts as a biostimulator that signals the skin to renew its own collagen, elastin and extracellular matrix. These fibres and support proteins naturally thin with age, so rebuilding them restores firmness and resilience where laxity first appears. It shares this collagen-stimulating principle with treatments like our polynucleotides.
Structura is designed to strengthen the underlying tissue, not to enhance volume or change facial shape. The improvement comes from your own regenerated tissue, so the outcome looks like a naturally better-supported version of your face rather than a filled or altered one.
No. Structura works structurally within the skin rather than on muscle, so it never freezes movement or alters your expressions. It works with your anatomy to improve support quietly and naturally.
The remodelling of collagen and elastin continues quietly in the weeks after each session. The change comes from your own regenerated tissue, so the firming and definition develop gradually and keep improving for up to six months following your second session.
From your first consultation to your follow-up review, your Profhilo Structura treatment at our Marylebone clinic is carried out by one of our doctors, Dr Joney De Souza or Dr Mattia Parducci. The treatment builds structural support gradually, so each stage is planned around your skin and your goals.
Your practitioner assesses your skin’s firmness, density and early signs of laxity around the cheeks, jawline and lower face. Structura is deeper and more structural than standard Profhilo, so they explain exactly how it differs and whether it suits your goals. You leave the consultation with a clear, personalised plan before any treatment begins.
On the day, the treatment area is gently cleansed and a topical anaesthetic may be applied for comfort. Using precise injection techniques, your practitioner delivers the hybrid hyaluronic acid into the deeper structural layers at carefully mapped points. The appointment takes around 45 minutes, and most patients find it quick and comfortable.
You can return to most normal activities straight away, avoiding strenuous exercise, heat and pressure on the area for 24 to 48 hours. A second session is performed about four weeks later, when your practitioner reviews your progress and plans maintenance every six to nine months. You also receive clear written aftercare guidance to protect your result.
Structura works at a deeper structural level than standard Profhilo, so injection technique and anatomical judgement matter enormously. Every session here is carried out by one of our doctors, Dr Joney De Souza or Dr Mattia Parducci. Your consultation is with Dr Joney De Souza or Dr Mattia Parducci, at our Marylebone clinic near Harley Street.
“My ‘less is more’ approach has become the mainstay of my practice and clients appreciate that they will have natural looking results” Dr Joney De Souza, The Sybarite
Profhilo Structura is a medical treatment, so every plan begins with a proper consultation to confirm your suitability and reduce risk before any injection. Your doctor carries out this assessment personally and provides clear written aftercare, so you are cared for to a genuine medical standard at every stage.
His thinking looks beyond the appointment to skin longevity, encouraging your own collagen to strengthen the deeper structure so the firmness and support you build hold up quietly for longer.
Profhilo Structura starts from £400 at our Marylebone clinic, which covers a course of two sessions spaced four weeks apart. Every face is different, so the right plan depends on your skin, the areas being treated and how much support they need. The guide below helps you understand which approach may suit you.
Pricing depends on your treatment areas and the plan you agree, so your exact investment and any recommended maintenance will be confirmed at your personal consultation.
| Treatment | Dr Joney (£) | Associated Clinician (£) |
|---|---|---|
Face | 475 | 400 |
Profhilo Structura and standard Profhilo are natural partners because they do complementary jobs. Structura is placed deeper to firm and support the lower face and jawline, while standard Profhilo spreads through the skin to boost overall hydration, radiance and glow across the wider face. Using them together treats both the structure and the surface, giving a more complete and balanced rejuvenation.
Structura strengthens the foundation first, so it can make the results of standard Profhilo look even more refined and better supported. Both treatments use hyaluronic acid and work with your own tissue rather than against your features, so they sit comfortably within one plan. Your practitioner will recommend the right sequence and combination for your skin at your consultation, and may also discuss where our wider range of skin boosters fits alongside them.

Below are the questions patients most often ask about Profhilo Structura at our Marylebone clinic. Structura works differently from standard Profhilo and from dermal fillers, so understanding how it firms and supports the skin helps you decide whether it suits your goals.
Profhilo Structura starts from £900 at our Marylebone clinic, which covers a course of two sessions spaced four weeks apart. Every face is different, so your exact plan and any recommended maintenance will be confirmed at consultation. Most patients budget for the initial two-session course plus a maintenance session every six to nine months.
Downtime is minimal after Profhilo Structura. The product is injected at precise points, so you may notice small bumps, mild redness or slight swelling that typically settle within a few hours to 24 hours. Most patients return to normal activities straight away, avoiding strenuous exercise and heat for 24 to 48 hours.
Early improvements in hydration and skin texture may appear within days of your first session. The firming and lifting then develop gradually over several weeks as collagen and elastin production increases. Results continue to improve for up to six months following the second session and generally last between six and twelve months.
Profhilo Structura uses a well-established hybrid hyaluronic acid, a substance found naturally in the skin. The treatment is carried out by one of our doctors, Dr Joney De Souza or Dr Mattia Parducci, and your consultation is with Dr Joney De Souza or Dr Mattia Parducci. A medical consultation comes first, so your doctor confirms your suitability and reduces risk before any injection. Side effects are usually limited to temporary redness or small bumps at the injection points.
No. Structura enhances the firmness and quality of your skin without changing your facial features. It strengthens and supports rather than adds volume, so the result is a naturally refreshed, subtly lifted appearance that looks like you, only better supported. If you are more concerned about lost fullness in the cheeks or a loss of volume, we may suggest a different approach at consultation.
Standard Profhilo spreads through the skin to boost overall hydration and glow, whereas Structura is placed deeper to firm and support the structure of the lower face and jawline. Think of Structura as structural reinforcement, and standard Profhilo as a hydration and radiance treatment.
Unlike dermal fillers, Structura does not add volume or change your facial shape. Its purpose is to strengthen and remodel the underlying tissue, so the result is firmer, more elastic skin rather than augmentation. Fillers are chosen where genuine volume or projection is needed, while Structura is chosen to rebuild support and density.
Yes, Structura pairs well with several treatments to enhance overall rejuvenation. It strengthens the deeper layers, so your practitioner may combine it with standard Profhilo, dermal fillers, microneedling, mesotherapy or energy-based tightening for a fully balanced plan. They will recommend the right combination for your skin at your consultation.
Patients across London trust Dr Joney De Souza for natural, balanced results. Every review reflects our commitment to precision, safety and a personalised approach to aesthetic care at our Marylebone clinic.
I highly recommend Dr. Joney and his clinic. I have been his patient for many years and he is definitely one of the best. His work is natural and subtle, he always puts the patient’s interest first and will never try to upsell unnecessary treatments.
Had an excellent experience today getting the Profhilo treatment done by Dr. Joney De Souza. The entire team was so friendly, and prepped me about what I should expect during and after the treatment.
Dr Joney is the most wonderful Dr, kind and caring and highly experienced. I feel safe in his care and trust his opinion 100%.