Profhilo Structura in Marylebone at Dr Joney De Souza Clinic delivers advanced skin hydration and firmness. This next-generation treatment strengthens tissue, enhances elasticity and restores youthful structure.
Profhilo Structura suits patients who notice early-to-moderate loss of facial architecture — a hollowing at the cheeks, softening of the jawline or a general loss of the structural firmness that defined their face in younger years. In particular, patients who have already benefited from standard Profhilo for skin hydration and bioremodelling may find that Structura addresses the deeper structural component that Profhilo alone does not reach. Most patients choose Profhilo Structura for one or more of the following concerns:
Profhilo Structura is most effective in adults aged 35 to 65 who retain adequate skin quality but have lost some facial architecture. However, your specialist carries out a thorough consultation before treatment to confirm that Structura is the most appropriate approach for your specific concerns and to set realistic expectations for the outcome.
Profhilo Structura is a next-generation injectable biostimulator developed by IBSA, the same manufacturer as standard Profhilo. However, unlike standard Profhilo — which uses a pure, uncross-linked hyaluronic acid formulation designed to spread through the superficial tissue and remodel skin quality — Structura contains a high-concentration hybrid cooperative complex of hyaluronic acid with a proprietary cross-linker. This formulation maintains its placement at deeper tissue level, providing a structural scaffold effect alongside collagen and elastin stimulation.
In practice, your specialist injects Profhilo Structura at specific anatomical points on the face, placing it at the periosteum or deep fascial level to support the overlying facial architecture. At Dr Joney De Souza Clinic in Marylebone, Profhilo Structura treatments follow a two-session protocol — sessions four to six weeks apart — and combine well with standard Profhilo for patients who want both structural support and surface-level bioremodelling.
Profhilo Structura uses a structured hyaluronic acid formulation placed at a deeper tissue level than standard skin biostimulators, providing a scaffold effect that supports facial architecture and stimulates collagen and elastin production over time.
Before treatment, your specialist conducts a full consultation to assess your facial architecture, degree of structural laxity and skin quality. Specifically, they map the areas of greatest structural loss and decide on the placement points for Profhilo Structura based on your individual anatomy. Your specialist also reviews your medical history to confirm there are no contraindications and discusses realistic expectations for the result. Before committing to treatment, you can ask any questions at this initial consultation.
No topical anaesthetic is required before Profhilo Structura, as the treatment uses fine-gauge needles and most patients find it well tolerated without numbing. However, your specialist advises you to avoid blood-thinning supplements such as fish oil, vitamin E and aspirin (unless prescribed) for one week before treatment to reduce bruising risk. Additionally, arrive with clean, product-free skin and without makeup on the treatment day.
Your specialist cleanse the face and marks the anatomical injection points. Profhilo Structura targets five points per side, placed at the deep tissue level to provide structural support at the cheeks, jawline and mid-face. Each injection takes only seconds, and your specialist applies gentle pressure after each placement to distribute the product appropriately. In practice, the entire treatment takes 30 minutes, and patients experience only mild pressure at each injection point during the procedure.
Immediately after treatment, small bumps at each injection point are normal and typically resolve within two to four hours. Some patients experience mild redness or minor bruising at the treated areas. Your specialist applies a soothing product before you leave and advises you to avoid makeup, touching the face and heat exposure for 24 hours. You can return to work and normal daily activities immediately after treatment.
The recommended protocol for Profhilo Structura involves two sessions four to six weeks apart. In the weeks following your first session, you may notice early improvements in facial firmness and skin quality as the biostimulation process begins. However, the full structural result only becomes apparent after both sessions are complete and the collagen and elastin stimulation has developed, typically over two to three months from your second appointment.
Profhilo Structura produces improvements in facial firmness, structure and skin quality that develop progressively over two to three months following the two-session course. Most patients notice sustained structural improvement for 9 to 12 months, after which a single maintenance session helps sustain the result. Furthermore, patients who combine Profhilo Structura with standard Profhilo report the most comprehensive improvement, as the two products address different tissue depths and aspects of facial ageing.
Profhilo Structura addresses structural support at a deeper tissue level, while standard Profhilo targets hydration and bioremodelling at the superficial level. In practice, your specialist may recommend both treatments to address facial ageing comprehensively — Structura for architecture and lift, standard Profhilo for skin quality and radiance. The two treatments complement each other and can be combined at the same appointment or in a staged plan at your specialist’s recommendation.
Profhilo Structura typically involves two sessions four to six weeks apart, followed by a review once the full result has developed at two to three months. Many patients choose a single maintenance session every 9 to 12 months thereafter to sustain the structural improvement and skin quality achieved from their initial course.
Before your appointment, avoid blood-thinning supplements including fish oil, vitamin E and aspirin (unless medically prescribed) for one week to reduce bruising risk. Additionally, avoid alcohol for 24 hours before treatment. On the day, arrive with clean, product-free skin and no makeup. Your specialist conducts a brief assessment at the start of the appointment to confirm the placement plan before proceeding with treatment.
Your specialist cleanses the face and marks the anatomical injection points. The treatment involves five injection points per side, placed at the deep tissue level using fine-gauge needles. In practice, most patients find Profhilo Structura comfortable without anaesthetic. The entire procedure takes 30 minutes, and you leave the clinic immediately after — no recovery time is needed before returning to your normal activities.
Small bumps at the injection points are normal immediately after treatment and resolve within two to four hours. As advised, avoid makeup, touching the treated areas and heat exposure for 24 hours. In the first week, you may notice early improvements in skin quality and firmness. However, the full structural result develops progressively over two to three months following the second session, as collagen and elastin stimulation takes effect in the deeper tissue.
At Dr Joney De Souza Clinic in Marylebone, Profhilo Structura treatments are carried out by Dr Joney and specialist practitioners with training in deep facial anatomy and the precise placement techniques required for structural biostimulators. In practice, this means each treatment plan starts with a detailed assessment of your facial architecture before any product is placed.
Dr Joney De Souza has over 20 years of experience in aesthetic medicine in London and maintains an approach to injectable treatments that prioritises anatomy and proportion over volume. For Profhilo Structura specifically, this means placing the product at the correct depth for each patient’s facial structure rather than adopting a generic protocol — a distinction that significantly affects both the safety and the quality of the result.
Profhilo Structura is a two-session treatment, with sessions four to six weeks apart. Pricing below covers a single session; a course of two sessions is available at a reduced rate. Both associate and Dr Joney pricing options are available.
| Treatment | Price |
|---|---|
Structura Face - therapist | 400 |
Structura Face 2x - therapist | 680 |
Structura Face - Dr Joney | 475 |
Structura Face 2x - Dr Joney | 800 |
Standard Profhilo uses a pure, uncross-linked hyaluronic acid formulation that spreads through the superficial tissue to remodel skin quality, improve hydration and restore radiance. In practice, many patients combine Profhilo Structura with standard Profhilo to address both the structural and surface aspects of facial ageing in a single treatment plan. Furthermore, the two products work synergistically — Structura builds the architecture from deep tissue up, while Profhilo improves the quality and luminosity of the overlying skin. Your specialist can advise on the most appropriate combination at your consultation.
Patients considering Profhilo Structura often arrive with questions about how it differs from standard Profhilo, what results to expect, how many sessions they need and what the downtime involves. The answers below cover the most common questions we hear at Dr Joney De Souza Clinic — from the treatment protocol and how it compares with dermal filler to how to combine it with other treatments for the best overall result.
Profhilo Structura is an injectable biostimulator developed by IBSA using a high-concentration hybrid cooperative complex of hyaluronic acid with a proprietary cross-linker. Unlike standard Profhilo, which spreads through the superficial tissue to remodel skin quality, Structura maintains its placement at the deep tissue level — at the periosteum or deep fascia — and provides a structural scaffold effect alongside collagen and elastin stimulation. In practice, your specialist treats both hands in a single session of 30 minutes, with results developing progressively over two to three months.
Standard Profhilo and Profhilo Structura both use hyaluronic acid formulations developed by IBSA, but they target different tissue levels and aspects of facial ageing. Standard Profhilo uses a pure, uncross-linked HA that spreads through the superficial tissue to improve hydration, skin quality and surface bioremodelling. By contrast, Profhilo Structura uses a more structured, cross-linked formulation placed at the deep tissue level to provide structural support and stimulate collagen and elastin from the foundation of the face upwards. In practice, many patients benefit from both products used together.
Profhilo Structura suits adults aged approximately 35 to 65 who have early-to-moderate loss of facial architecture — including hollowing at the cheeks, softening of the jawline or a loss of facial firmness that differs from volume loss alone. However, the treatment is not suitable for patients who are pregnant or breastfeeding, those with active infections over the treatment area, or patients with certain autoimmune or clotting conditions. Your specialist screens for all contraindications at the initial consultation.
The standard starting protocol for Profhilo Structura is two sessions, four to six weeks apart. This two-session course provides the full structural biostimulation effect and allows collagen and elastin stimulation to develop progressively. After completing the initial course, most patients maintain their result with a single top-up session every 9 to 12 months. In practice, your specialist reviews the result at two to three months after the second session before recommending the most appropriate maintenance schedule.
Profhilo Structura results typically last 9 to 12 months following the two-session starting course, as the structural support and collagen stimulation gradually diminish over time. However, patients who combine Profhilo Structura with standard Profhilo and return for a maintenance session within the recommended timeframe tend to sustain the result with a smaller top-up volume than the original treatment required. In practice, your specialist advises on the most appropriate maintenance schedule based on how your result develops over the months following your initial course.
Most patients find Profhilo Structura comfortable and well tolerated without anaesthetic, as the treatment uses fine-gauge needles and the number of injection points is small — five per side. In practice, most patients describe the sensation as mild pressure or a brief sting at each injection point. The entire treatment takes 30 minutes, and no recovery time is needed before leaving the clinic or returning to normal activities.
Profhilo Structura has minimal downtime. Small bumps at the injection sites are normal immediately after treatment and typically resolve within two to four hours. Some patients experience mild redness or minor bruising. In practice, you can return to work and normal activities immediately after the procedure. Your specialist advises you to avoid makeup, touching the treated areas, intense exercise and heat exposure for 24 hours after treatment.
Profhilo Structura combines well with standard Profhilo, polynucleotides, anti-wrinkle injections and dermal filler, depending on your specific concerns. In practice, combining Structura with standard Profhilo is the most common combination — Structura addresses facial architecture at the deep tissue level, while Profhilo improves surface skin quality and hydration. Your specialist designs a combination plan tailored to your concerns and budgets at your consultation, staging treatments appropriately for the best overall result.
Profhilo Structura targets specific anatomical points at the deep tissue level — typically five points per side — placed at the periosteum or deep fascia of the cheeks, jawline and mid-face. These placement points differ from the BAP (Bio Aesthetic Point) technique used for standard Profhilo. In practice, the exact placement varies by patient anatomy and the areas of greatest structural loss, which your specialist maps at the initial assessment.
Patients typically notice early improvements in facial firmness and skin quality within a few weeks of the first session. However, the full structural result — improved facial architecture, lifted appearance at the cheeks and jawline, and improved skin firmness — develops progressively over two to three months following the second session. In practice, results are gradual and natural-looking rather than immediately obvious, which suits patients who want improvement without a visibly treated appearance.
Book via WhatsApp at the number listed on this page, or by completing the consultation form above. Consultations take 30 to 45 minutes and include a full facial assessment, a review of your medical history and a discussion of realistic outcomes. Treatment can proceed at the same appointment if appropriate. The team aims to respond to all enquiries within one working day.
Once patients understand what Profhilo Structura does, the most common questions concern how it compares with dermal filler, standard Profhilo and collagen stimulators such as Sculptra — and how to combine treatments for the most comprehensive result. The answers below address the most frequent comparisons we hear at Dr Joney De Souza Clinic, from treatment longevity and suitability to aftercare and booking.
Profhilo Structura and dermal filler are different in mechanism and indication. Dermal filler directly replaces lost volume and can add definition to specific areas such as the lips, cheeks or jawline with immediate, visible results. By contrast, Profhilo Structura does not add volume in the same way — instead, it provides structural support and stimulates collagen and elastin production over time for a more gradual, natural-looking improvement in firmness. In practice, your specialist recommends the most appropriate option based on whether your concern is volume loss, structural laxity or both.
Both Profhilo Structura and Sculptra are collagen biostimulators that work progressively rather than immediately. Sculptra uses poly-L-lactic acid to stimulate collagen over a series of three to four sessions, with results lasting up to two years. Profhilo Structura uses a structured hyaluronic acid complex placed at the deep tissue level, with a two-session protocol and results lasting 9 to 12 months. In practice, your specialist advises on which product best suits your degree of laxity and your goals — Sculptra tends to suit greater volume loss over a wider area, while Structura targets the facial architecture more precisely.
Profhilo Structura does not replace standard Profhilo — the two products address different aspects of facial ageing. Standard Profhilo targets skin hydration, radiance and bioremodelling at the superficial tissue level, while Profhilo Structura addresses structural support and collagen stimulation at the deeper tissue level. In practice, many patients benefit most from using both products together — Structura for the architectural foundation and standard Profhilo for skin quality improvement. Your specialist discusses the most appropriate plan at your consultation.
Profhilo Structura is most effective for adults aged approximately 35 to 65 who have early-to-moderate loss of facial architecture and sufficient remaining skin quality. Patients with significant skin laxity or pronounced jowling may need more structural intervention — such as Endolift or Ultherapy — before or alongside Profhilo Structura. In practice, your specialist assesses your facial architecture at the initial consultation and recommends the most appropriate treatment or combination plan for your age and concerns.
In the week before Profhilo Structura, avoid blood-thinning supplements including fish oil, vitamin E and aspirin (unless medically prescribed), as these increase the risk of bruising at the injection sites. Additionally, avoid alcohol for 24 hours before treatment. On the day, arrive with clean skin free of makeup, moisturiser and SPF products. In practice, your specialist provides a full pre-treatment checklist at your consultation to ensure you prepare for the procedure effectively.
After Profhilo Structura, avoid touching or pressing the treated areas for 24 hours to allow the product to settle. Additionally, avoid makeup, intense exercise, saunas and alcohol for 24 hours after the procedure. Keep the skin moisturised with a gentle, fragrance-free product in the days following treatment. Furthermore, wearing SPF on the face throughout the weeks after treatment protects the skin and supports the overall quality and longevity of the biostimulation result.
Profhilo Structura produces a gradual, natural-looking improvement in facial firmness and structure rather than an immediate visible change. Because the result develops progressively over two to three months, patients often describe the outcome as looking like a refreshed, more structured version of themselves — an improvement that others notice without being able to identify the cause. In practice, the clinic’s approach to Profhilo Structura prioritises a result that is proportionate and appropriate for the patient’s age and facial anatomy.
Early improvements in skin quality and surface firmness often begin within two to three weeks of the first Profhilo Structura session. However, the full structural result — improved facial architecture, lifted appearance at the cheeks and jawline — develops progressively over two to three months following the second session, as collagen and elastin stimulation takes effect. In practice, your specialist reviews the result at the two to three month mark to assess the outcome and advise on maintenance timing.
Yes, Profhilo Structura and standard Profhilo can be combined at the same appointment or in a planned sequence, depending on your specialist’s recommendation and your tolerance for treatment. In practice, combining both products in the same session is sometimes appropriate for patients who want to address both structural laxity and surface skin quality simultaneously. However, your specialist may prefer to stage the treatments to allow each product to settle before assessing the result and planning the next step. The most appropriate approach is confirmed at your consultation.
Profhilo Structura at Dr Joney De Souza Clinic starts from £400 per session with an associate practitioner. A course of two sessions (the recommended starting protocol) is from £680. Dr Joney De Souza pricing starts from £475 per session, or £800 for a course of two. Consultations are complimentary. Final pricing is confirmed at the initial consultation, where your specialist recommends the most appropriate treatment plan based on your facial assessment.
Book via WhatsApp or by completing the consultation form at the top of this page. Consultations take 30 to 45 minutes and include a full facial assessment, a discussion of realistic outcomes and the opportunity to proceed with treatment at the same appointment if appropriate. The clinic is centrally located in Marylebone, close to Baker Street and Bond Street underground stations. The team aims to respond to all enquiries within one working day.
Our patients return to us year after year for natural, balanced results. Every review reflects our commitment to precision, safety and a personalised approach to aesthetic care.
Profhilo Structura has made a remarkable difference to the structure and firmness of my face. I look naturally lifted without looking overdone. Dr De Souza is incredibly skilled and the whole team are wonderful.
I had Profhilo Structura for facial laxity and the improvement has been exceptional. My face looks lifted and more defined. The treatment was quick and comfortable and I was back to normal straight away.
Dr Joney is an exceptional practitioner. My Profhilo Structura results are beautiful — my skin looks firmer and the treatment was very natural-looking. I highly recommend this clinic.
Outstanding clinic and outstanding results. Profhilo Structura has restored the definition to my jawline and cheeks. The team were thorough, professional and very reassuring throughout.
