Profhilo Structura in Marylebone, London

Firm and define your lower face and jawline with Profhilo Structura at Dr Joney De Souza in Marylebone, London. Doctor-led, natural results from £900. Book today.

Profhilo Structura

time-graphic
Procedure time
Around 45 minutes per session
laptop-graphic
Back to work
Same day, downtime is minimal
heart-graphic
Anaesthetic
Topical numbing given as needed
recovery-graphic
Results appear
Hydration within days; firming builds over weeks
warning-graphic
Results last
6 to 12 months, with maintenance every 6 to 9 months
Price From
£400
for a course of 2 sessions, 4 weeks apart

Who Is Profhilo Structura For?

If your jawline has started to soften and your lower face looks a little less defined than it once did, Profhilo Structura is built for exactly that moment. It works within the deeper structural layers of the skin, so it suits early to moderate laxity, the stage where definition first begins to fade but volume is still intact. You may recognise yourself in one or more of the concerns below.

  • Early to moderate skin laxity around the cheeks, jawline and lower face
  • Reduced firmness or thinning skin that has started to lose structure
  • Loss of definition along the jawline or hollowing at the temples
  • A preference for natural regeneration rather than filler-style volume
  • A wish to maintain skin strength proactively before laxity becomes pronounced

Profhilo Structura is at its best firming and supporting the lower face and restoring definition naturally. If your priority is heavier jowls, deep folds or lost volume, we will guide you to the right option at your consultation.

 

fine-lines-close

As Seen In

Sunday-times-logo
OK-magazine-logo
ES-magazine-logo
FT-logo
Tatler-logo
Grazia-logo
Harpers-Bazaar-logo
GQ-logo

What Is Profhilo Structura?

Profhilo Structura is an advanced injectable from the Profhilo family, developed specifically to firm and support the deeper structure of the skin. Standard Profhilo sits near the surface to hydrate and add glow. Structura is placed deeper, reinforcing the structural layers and superficial fat compartments that give the face its shape. As Dr Joney De Souza told Forbes, “The ones that contain solely hyaluronic acid in very high concentration (Profhilo)…” reward the skin with quality rather than bulk (Forbes).

Structura reinforces rather than fills, so the result looks like a naturally better-supported version of your own face. It never freezes movement or alters your expressions. Around 95 percent of patients notice lasting enhancement of the mid-face, which is why it is a favourite for restoring quiet definition without changing a patient’s features.

Related treatments at Dr Joney De Souza: standard Profhilo, our skin boosters, polynucleotides and a sagging jawline.

How Does Profhilo Structura Work?

Profhilo Structura delivers a highly concentrated hybrid hyaluronic acid, a substance your skin already produces naturally, into the deeper structural layers of the face. The formulation is denser and placed deeper than standard Profhilo, so it draws and holds water within the tissue while acting as a biostimulator that signals the skin to renew its own collagen, elastin and extracellular matrix. Put simply, it rebuilds the scaffolding that supports the lower face instead of laying filler-style volume on top.

Key Benefits

  • Firms and strengthens the deeper structure of the skin
  • Improves definition along the cheeks, jawline and temples
  • Stimulates your own collagen and elastin for lasting resilience
  • Restores density and support without adding unwanted volume
  • Delivers a natural result that never changes your features or expressions
  • Improves hydration and skin quality from within
  • Continues to improve for up to six months following your second session

Where in the skin does Structura sit?

Profhilo Structura is placed deeper than standard Profhilo, within the structural layers of the skin and the superficial fat compartments. These are the tissues that give the lower face its shape and support, so working at this depth reinforces the scaffolding rather than adding volume near the surface.

What is the hybrid hyaluronic acid?

The formulation is a highly concentrated hybrid hyaluronic acid, a substance your skin already produces naturally. It is denser than the version used in standard Profhilo, engineered to firm and support rather than simply hydrate the outer layers.

How does it stimulate collagen and elastin?

Once injected, the hybrid hyaluronic acid acts as a biostimulator that signals the skin to renew its own collagen, elastin and extracellular matrix. These fibres and support proteins naturally thin with age, so rebuilding them restores firmness and resilience where laxity first appears. It shares this collagen-stimulating principle with treatments like our polynucleotides.

Why does it firm rather than fill?

Structura is designed to strengthen the underlying tissue, not to enhance volume or change facial shape. The improvement comes from your own regenerated tissue, so the outcome looks like a naturally better-supported version of your face rather than a filled or altered one.

Does it affect facial movement?

No. Structura works structurally within the skin rather than on muscle, so it never freezes movement or alters your expressions. It works with your anatomy to improve support quietly and naturally.

Why do results keep improving after treatment?

The remodelling of collagen and elastin continues quietly in the weeks after each session. The change comes from your own regenerated tissue, so the firming and definition develop gradually and keep improving for up to six months following your second session.

Your Profhilo Structura Journey

From your first consultation to your follow-up review, your Profhilo Structura treatment at our Marylebone clinic is carried out by one of our doctors, Dr Joney De Souza or Dr Mattia Parducci. The treatment builds structural support gradually, so each stage is planned around your skin and your goals.

Before Your Treatment

Your practitioner assesses your skin’s firmness, density and early signs of laxity around the cheeks, jawline and lower face. Structura is deeper and more structural than standard Profhilo, so they explain exactly how it differs and whether it suits your goals. You leave the consultation with a clear, personalised plan before any treatment begins.

During Your Session

On the day, the treatment area is gently cleansed and a topical anaesthetic may be applied for comfort. Using precise injection techniques, your practitioner delivers the hybrid hyaluronic acid into the deeper structural layers at carefully mapped points. The appointment takes around 45 minutes, and most patients find it quick and comfortable.

After Your Treatment

You can return to most normal activities straight away, avoiding strenuous exercise, heat and pressure on the area for 24 to 48 hours. A second session is performed about four weeks later, when your practitioner reviews your progress and plans maintenance every six to nine months. You also receive clear written aftercare guidance to protect your result.

Why Dr Joney De Souza Clinic?

Structura works at a deeper structural level than standard Profhilo, so injection technique and anatomical judgement matter enormously. Every session here is carried out by one of our doctors, Dr Joney De Souza or Dr Mattia Parducci. Your consultation is with Dr Joney De Souza or Dr Mattia Parducci, at our Marylebone clinic near Harley Street.

“My ‘less is more’ approach has become the mainstay of my practice and clients appreciate that they will have natural looking results” Dr Joney De Souza, The Sybarite

  • Doctor-led throughout: a doctor assesses your skin and performs every Structura injection.
  • Lower-face and jawline expertise: Structura is placed to strengthen and define the areas where laxity shows first, without adding unwanted volume.
  • Natural, structural results: the treatment rebuilds support beneath the skin, so you look firmer and more defined rather than filled or altered.
  • Marylebone location: the clinic sits in the heart of Marylebone, close to Harley Street and easily reached from across central London.

A Medical Standard of Care

Profhilo Structura is a medical treatment, so every plan begins with a proper consultation to confirm your suitability and reduce risk before any injection. Your doctor carries out this assessment personally and provides clear written aftercare, so you are cared for to a genuine medical standard at every stage.

His thinking looks beyond the appointment to skin longevity, encouraging your own collagen to strengthen the deeper structure so the firmness and support you build hold up quietly for longer.

Profhilo Structura Pricing

Profhilo Structura starts from £400 at our Marylebone clinic, which covers a course of two sessions spaced four weeks apart. Every face is different, so the right plan depends on your skin, the areas being treated and how much support they need. The guide below helps you understand which approach may suit you.

Which Profhilo Structura Plan Is Right for You?

  • Standard two-session course: suits most patients and is the recommended starting point to achieve the full firming and lifting effect.
  • Course plus a third session: some patients with more advanced laxity or thinning skin benefit from an additional session for a stronger result.
  • Ongoing maintenance: a single session every six to nine months preserves the density and support you have built.

Pricing depends on your treatment areas and the plan you agree, so your exact investment and any recommended maintenance will be confirmed at your personal consultation.

TreatmentDr Joney (£)Associated Clinician (£)

Face

475

400

Combine with Standard Profhilo

Profhilo Structura and standard Profhilo are natural partners because they do complementary jobs. Structura is placed deeper to firm and support the lower face and jawline, while standard Profhilo spreads through the skin to boost overall hydration, radiance and glow across the wider face. Using them together treats both the structure and the surface, giving a more complete and balanced rejuvenation.

Structura strengthens the foundation first, so it can make the results of standard Profhilo look even more refined and better supported. Both treatments use hyaluronic acid and work with your own tissue rather than against your features, so they sit comfortably within one plan. Your practitioner will recommend the right sequence and combination for your skin at your consultation, and may also discuss where our wider range of skin boosters fits alongside them.

Explore Profhilo

Profhilo Structura: Frequently Asked Questions

Below are the questions patients most often ask about Profhilo Structura at our Marylebone clinic. Structura works differently from standard Profhilo and from dermal fillers, so understanding how it firms and supports the skin helps you decide whether it suits your goals.

How much does Profhilo Structura cost at Dr Joney De Souza in Marylebone?

Profhilo Structura starts from £900 at our Marylebone clinic, which covers a course of two sessions spaced four weeks apart. Every face is different, so your exact plan and any recommended maintenance will be confirmed at consultation. Most patients budget for the initial two-session course plus a maintenance session every six to nine months.

Is there any downtime after Profhilo Structura?

Downtime is minimal after Profhilo Structura. The product is injected at precise points, so you may notice small bumps, mild redness or slight swelling that typically settle within a few hours to 24 hours. Most patients return to normal activities straight away, avoiding strenuous exercise and heat for 24 to 48 hours.

When will I see results from Profhilo Structura?

Early improvements in hydration and skin texture may appear within days of your first session. The firming and lifting then develop gradually over several weeks as collagen and elastin production increases. Results continue to improve for up to six months following the second session and generally last between six and twelve months.

Is Profhilo Structura safe, and who performs it?

Profhilo Structura uses a well-established hybrid hyaluronic acid, a substance found naturally in the skin. The treatment is carried out by one of our doctors, Dr Joney De Souza or Dr Mattia Parducci, and your consultation is with Dr Joney De Souza or Dr Mattia Parducci. A medical consultation comes first, so your doctor confirms your suitability and reduces risk before any injection. Side effects are usually limited to temporary redness or small bumps at the injection points.

Will I look different after Profhilo Structura?

No. Structura enhances the firmness and quality of your skin without changing your facial features. It strengthens and supports rather than adds volume, so the result is a naturally refreshed, subtly lifted appearance that looks like you, only better supported. If you are more concerned about lost fullness in the cheeks or a loss of volume, we may suggest a different approach at consultation.

How is Profhilo Structura different from standard Profhilo?

Standard Profhilo spreads through the skin to boost overall hydration and glow, whereas Structura is placed deeper to firm and support the structure of the lower face and jawline. Think of Structura as structural reinforcement, and standard Profhilo as a hydration and radiance treatment.

How does Profhilo Structura compare with dermal fillers?

Unlike dermal fillers, Structura does not add volume or change your facial shape. Its purpose is to strengthen and remodel the underlying tissue, so the result is firmer, more elastic skin rather than augmentation. Fillers are chosen where genuine volume or projection is needed, while Structura is chosen to rebuild support and density.

Can Profhilo Structura be combined with other treatments?

Yes, Structura pairs well with several treatments to enhance overall rejuvenation. It strengthens the deeper layers, so your practitioner may combine it with standard Profhilo, dermal fillers, microneedling, mesotherapy or energy-based tightening for a fully balanced plan. They will recommend the right combination for your skin at your consultation.

4.9 ★★★★★

Read our reviews

Patients across London trust Dr Joney De Souza for natural, balanced results. Every review reflects our commitment to precision, safety and a personalised approach to aesthetic care at our Marylebone clinic.

I highly recommend Dr. Joney and his clinic. I have been his patient for many years and he is definitely one of the best. His work is natural and subtle, he always puts the patient’s interest first and will never try to upsell unnecessary treatments.

Had an excellent experience today getting the Profhilo treatment done by Dr. Joney De Souza. The entire team was so friendly, and prepped me about what I should expect during and after the treatment.

Dr Joney is the most wonderful Dr, kind and caring and highly experienced. I feel safe in his care and trust his opinion 100%.

Shelley Maxwell
Shelley Maxwell
View on Google

Follow us on Instagram

Lip flip vs lip filler. Which one is right for you? Swipe through to find out 👉

Two very different treatments. Two very different results. And yet they are confused for each other constantly, so let us clear it up...

The lip flip
A lip flip uses a small amount of muscle-relaxing product placed into the muscle just above the upper lip. Rather than adding volume, it causes the upper lip to gently roll outward, creating the appearance of a fuller, more defined lip without any filler being used. The result is a subtle soft enhancement that works particularly well for anyone who feels their upper lip disappears when they smile, or who wants a more natural look without added volume. 

Lip filler
Lip filler uses hyaluronic acid to add volume, shape and definition to the lips. It can be used to enhance the overall size of the lips, define the lip border, correct asymmetry or restore volume that has been lost over time. The results are immediate and can be tailored precisely to what you are looking for - whether that is a subtle, natural enhancement or something more noticeable. 

So which one is for you? The best way to find out is by booking a consultation with us where your individual anatomy, goals and expectations can be properly assessed.

📍Marylebone, London | 020 7043 0748 📱The SPF market can feel overwhelming, and we completely understand why 👇

Too many options, too many textures, too many excuses. So let us make it simple.

We hear the same things all the time. It breaks me out. It leaves a white cast. It feels greasy. I just cannot be bothered. And honestly? Every single one of those concerns is valid. But in 2026, none of them are reasons not to wear SPF anymore.

The ZO Skin Health SPF range, which we stock here at Dr Joney De Souza Skin & Laser, has an option for every single skin type, concern and lifestyle. And we mean that.

💭Oily or acne-prone skin? The Sheer Fluid SPF 50 is lightweight, oil-free and non-comedogenic. No breakouts. No shine.

💭Want your SPF to double as a primer? The Sunscreen + Primer SPF 30 creates a flawless base for makeup in one step.

💭Need something for active days or the beach? The Daily Sheer SPF 50 is water resistant and suitable for all skin tones with zero white cast.

💭Want a little coverage too? The Smart Tone SPF 50 adapts to your skin tone for a subtle, skin-perfecting finish.

And for anyone who just cannot be bothered with reapplying? The Sunscreen + Powder SPF 30 is a brush-on powder that goes straight over your makeup, tops up your protection and controls shine at the same time. No fuss. No excuses.

There is an SPF for everyone. Come and find yours today 🤍Profhilo vs Profhilo Structura - what is the difference? 👉

Both are injectable treatments containing hyaluronic acid. Both are produced by the same manufacturer. And both deliver beautiful, natural results. But they are not the same treatment, and understanding the difference is important when it comes to choosing the right one for your skin.

🫧 Profhilo
Profhilo is a skin booster. Its primary purpose is to deeply hydrate the skin, improve overall skin quality and stimulate the production of collagen and elastin. It spreads through the tissue to treat a wide area, leaving the skin looking more radiant, plump and youthful. It is suitable for a broad range of patients and is particularly effective for anyone experiencing dullness, dehydration or a general loss of skin glow.

🫧 Profhilo Structura
Profhilo Structura is specifically designed to address skin laxity and loss of firmness. It contains a higher concentration of high molecular weight hyaluronic acid, which works to remodel the deeper structural layers of the skin, restoring lift, firmness and definition in areas where the skin has begun to lose its architecture over time. It is particularly effective for the cheeks, jawline and neck.

Which one is right for you?
If your primary concern is skin quality, hydration and radiance, Profhilo is likely the right starting point. If you are noticing a loss of firmness, definition or lift, Profhilo Structura may be the more appropriate choice. For many patients, the two work beautifully together as part of a combined treatment plan.

The best way to find out is a thorough consultation with one of our medics 🤍Your guide to radiant summer skin ☀️

Summer is here, and your skin needs a little extra love. Swipe through for everything you need to know to keep your skin glowing all season long 👉

PicoSure targets pigmentation, sun damage and uneven skin tone at a cellular level - giving you a clearer, brighter complexion just in time for summer.

SPF 50, every single day. Non-negotiable. UV rays are present rain or shine, and no treatment or product can undo the damage of unprotected sun exposure. Apply every morning and reapply every two hours outdoors. 

Skin boosters deliver deep hydration from within - improving elasticity, smoothing texture and creating that natural, lit-from-within glow that no topical product can replicate. 

📍Marylebone, London | 020 7043 0748 📱

How can you find us?

Our clinic is located in Marylebone, London, in the heart of one of Central London’s most prestigious and renowned medical districts. Perfectly positioned for convenience and discretion, we are easily accessible from across the capital and beyond.

We welcome patients from Mayfair, Harley Street, Marylebone, Knightsbridge, Belgravia, Chelsea, Kensington, Fitzrovia and St John’s Wood, as well as international patients visiting London for specialist treatment.

Our location benefits from excellent transport connections, with close proximity to major Underground stations, mainline rail links and direct access to Heathrow, Gatwick and London City airports. Several secure parking facilities and convenient chauffeur drop-off points are available nearby, ensuring a seamless and comfortable visit.

Whether you are travelling from elsewhere in London, across the UK or internationally, our clinic offers a calm, private and exclusive setting in one of the world’s leading medical destinations.

Opening hours
Monday
9 am to 6 pm
Tuesday
9 am to 6 pm
Wednesday
9 am to 6 pm
Thursday
9 am to 6 pm
Friday
9 am to 6 pm
Saturday
Closed
Sunday
Closed
Dr Joney De Souza
49 Blandford St, London W1U 7HH
Get directions
Whatsapp