Doctor-led polynucleotide injections (Plinest Hair) at our Marylebone clinic help repair the scalp environment, calm inflammation and support stronger, denser-looking hair over a course. Assessed and performed by Dr Joney De Souza.
Many people arrive at the Dr Joney De Souza Clinic in Marylebone having noticed something small but unsettling. They want to act while there is still plenty to work with. Perhaps your parting looks wider than it did last year. Maybe your ponytail feels finer, or more strands than usual collect in the sink. Polynucleotides for hair suit men and women in exactly this window, when thinning is early to moderate and the follicles are still active. It is often the point at which a considered, longevity-minded approach to your scalp does the most good.
This is a treatment for follicles that are struggling, not follicles that have gone. If an area of scalp is genuinely bare, we will tell you plainly. The same honesty applies if your history points to a thyroid, iron or hormonal cause. Either way, we guide you toward the right answer first. Every patient is seen face to face by Dr Joney De Souza before a single session is booked.
Polynucleotides are highly purified fractions of DNA, suspended in a soft gel and placed in tiny amounts across the scalp. Plinest Hair is the dedicated hair line within the PN-HPT family, formulated for the follicular zone. The fractions are drawn from purified fish DNA, then cleaned to a medical grade. That process removes the protein that could trigger a reaction and leaves a biocompatible repair signal.
Once it is in the scalp, this signal helps repair and support the tissue around each follicle. It calms the low-grade inflammation that so often travels alongside thinning. Just as importantly, it improves the microcirculation and hydration of the skin your hair grows from. A helpful way to picture it is that we improve the soil rather than pull on the plant. Over a course, a healthier scalp environment gives the follicles you still have a better chance of producing stronger, denser-looking hair.
Hair thinning is rarely just about the hair itself. The scalp underneath is often inflamed, poorly supplied with blood and slow to repair. A follicle sitting in that environment gradually shrinks, producing a finer strand with each cycle. Polynucleotides work on that environment directly. The purified DNA fractions prompt the scalp’s own repair pathways. They draw in moisture, support the small vessels that feed each follicle and quiet the inflammation that drives miniaturisation. Dr Joney De Souza places a series of small, shallow injections across the thinning zones. He spaces them so the product reaches the follicular layer evenly.
Nothing about this is instant, and it would be dishonest to pretend otherwise. The scalp itself settles within a day or two. Over the following weeks, the underlying environment keeps improving. The follicles then respond in their own time. A hair has to move through its natural growth phase before you see the difference. A course of two to three sessions gives the tissue repeated, well-spaced signals to work with. That steady support is what long-term scalp and hair health depends on.
Your first appointment is with Dr Joney De Souza. He looks at the pattern of your thinning, examines the scalp and asks about your history. Shedding after a baby, after illness or after a stressful year behaves very differently from a genetic pattern. Where a medical cause seems likely, he will recommend the right checks before treatment rather than after.
The scalp is cleansed and the treatment areas are mapped. If you would like it, a topical numbing cream is applied and left to take effect. Most patients find this makes the session very comfortable.
Dr Joney De Souza places a series of fine, shallow injections across the thinning zones. He spaces them so the polynucleotides reach the follicular layer evenly. The injecting part usually takes around fifteen to twenty minutes. You may feel brief pressure or a light stinging at each point.
Some small bumps, mild redness and tenderness are normal and usually settle within twenty four to forty eight hours. You can go back to your day the same afternoon. We give you clear aftercare before you leave.
Before you go, Dr Joney De Souza confirms your recommended course, usually two to three sessions spaced a few weeks apart. He also talks through sensible maintenance once the initial course is done. There is no pressure to commit to a course on day one.
The whole experience is built around one short, well-tolerated appointment, repeated across a course. Most people are in and out within the hour and back at their desk the same afternoon. They quietly get on with life while the scalp does its work in the background. Here is what to expect around each session.
Come with clean, product-free hair if you can. Tell us in advance about any medication that thins the blood. Mention any scalp conditions, and whether you are pregnant or breastfeeding. These details change what is safe. Skip alcohol the night before to keep bruising to a minimum.
You relax in the treatment chair while the numbing cream, if you have chosen it, takes effect. Dr Joney De Souza then works methodically across the mapped areas with fine needles. Talk to us at any point. The active injecting is brief and most patients are surprised by how manageable it feels.
Leave the scalp alone for the first twelve hours. Avoid washing your hair or heavy exercise for the rest of the day. Give saunas, steam rooms and direct heat a miss for forty eight hours. Hold off on styling products and topical treatments for a day. Any redness or small bumps typically fade within a day or two.
Hair loss is emotive, and it attracts a great deal of noise and easy promises. What sets our Marylebone clinic apart is simple. Polynucleotides are treated here as a medical procedure, not a quick add-on. Dr Joney De Souza assesses every patient in person, confirms what is genuinely driving the thinning, and then performs the injections himself. The person judging your scalp is the same person treating it.
“I would rather turn a patient away than sell them a course that will not help. When I inject polynucleotides, it is because I have looked at the scalp and I believe the follicles are still worth supporting. That honesty is the whole point of a doctor-led clinic.” Dr Joney De Souza
Being candid matters just as much as the treatment itself. Polynucleotides for hair are not a cure, and they will not bring back hair from a scalp that is already bare. Results build gradually over a course and need sensible maintenance to hold. Some hair loss has a medical cause, such as a thyroid issue, low iron or a hormonal shift. That needs diagnosing before any injection makes sense. Conditions like alopecia areata or scarring alopecia call for a different route entirely. Advanced or complete baldness is usually better served by surgical options. We would always rather have that conversation at the start than watch you spend on the wrong thing.
Polynucleotides for hair start from £410 for a single session covering one area. A course of three is available at the rates shown below, and both the number of areas and the practitioner who treats you affect the fee. Your exact price is confirmed at consultation, once Dr Joney De Souza has seen your scalp. There is no obligation to book a course before your first session.
Polynucleotides and PRP approach hair from different angles. Many patients get their best result by pairing the two. Plinest Hair repairs and calms the scalp environment. PRP for hair uses concentrated growth factors from your own blood to prompt the follicles directly. Because the mechanisms complement rather than duplicate each other, Dr Joney De Souza will tell you at consultation whether one treatment or a combination makes sense for your scalp. He will also explain how the two might be sequenced across a course.
The questions patients ask us most often about polynucleotides for hair, answered plainly by our Marylebone team.
Polynucleotides are highly purified fractions of DNA, injected in small amounts across the scalp. Plinest Hair is the dedicated hair formulation. Rather than acting on the strand, they work on the scalp itself. They help repair the tissue around the follicle, calm inflammation and improve hydration and blood supply. The follicles you have then sit in a healthier environment and can produce stronger, denser-looking hair over a course.
Most patients have a course of two to three sessions spaced roughly four to six weeks apart, followed by maintenance every six to twelve months. The exact number depends on how much thinning you have and how your scalp responds. Dr Joney De Souza confirms your plan at consultation.
Early signs, such as a calmer scalp and less shedding, often show in the first four to six weeks. Visible changes in density and thickness generally take longer, around eight to twelve weeks. A hair has to move through its natural growth phase before you notice it. The fuller benefit of a course usually becomes clear around three to four months in. Results vary from person to person.
Results from a course typically last around six to twelve months. Much depends on what is driving your hair loss. It also depends on how you respond and how you care for your scalp at home. Maintenance sessions help sustain the improvement. Patients who also address underlying factors, such as a nutritional gap or a hormonal issue, tend to hold their results for longer.
Most patients find it very manageable, especially with the optional topical numbing cream. You may feel brief pressure and a light sting at each injection point. The needles are fine and the active injecting part is short. People are usually more comfortable than they expect.
Polynucleotides have a well-established safety record in regenerative medicine, and the DNA fractions are purified to a medical grade and well tolerated by scalp tissue. Mild redness, small bumps and tenderness are expected and settle within twenty four to forty eight hours. More significant reactions are rare when a qualified doctor treats you. At our clinic Dr Joney De Souza performs every injection.
Essentially none. You can return to work the same afternoon. Expect some redness or small bumps for a day or two. Avoid washing your hair and heavy exercise that day. Keep the scalp away from saunas and direct heat for forty eight hours.
Dr Joney De Souza performs the polynucleotide injections himself. This is a doctor-led treatment from the assessment through to the needle, which is exactly what a scalp procedure should be.
Leave the scalp alone for twelve hours and avoid washing your hair for the rest of the day. Skip intense exercise for twenty four hours, and hold off on styling products, minoxidil and other topical treatments for a day. Avoid saunas, steam rooms and direct heat for forty eight hours. Dr Joney De Souza confirms your specific aftercare at the end of each session.
Polynucleotides for hair are not suitable during pregnancy or breastfeeding. They are also unsuitable for anyone with an active scalp infection or a tendency to keloid scarring. The same applies with an autoimmune cause such as alopecia areata, scarring alopecia or certain clotting disorders. They also will not restore hair from a fully bare scalp. If a blood test points to a thyroid, iron or hormonal cause, that needs addressing first. Dr Joney De Souza reviews your history at consultation. He will tell you honestly if this is not the right treatment for you.
Yes, and they often work well together. PRP for hair adds growth factors that prompt the follicles directly, while a HydraFacial Keravive scalp cleanse clears buildup at the surface. Combining these as part of a fuller hair programme addresses the scalp on more than one level. Dr Joney De Souza will advise whether a combination suits you.
There is no single best hair treatment, only the one that fits your scalp and your stage of thinning. Here is how polynucleotides compare with the other options we offer, with honest answers on cost, safety, origin and booking.
Neither is universally better. Polynucleotides repair and calm the scalp environment and improve microcirculation, which suits scalps where inflammation is part of the picture. PRP for hair uses concentrated growth factors from your own blood to prompt the follicles more directly, which suits more active shedding. Many patients do best with both. Dr Joney De Souza will recommend one or a combination after seeing your scalp.
PRF (platelet-rich fibrin) is a second-generation version of PRP that releases growth factors more slowly from a fibrin scaffold, again using your own blood. Both PRF and polynucleotides share the goal of a healthier follicular environment, yet they reach it differently. One works through your own biology, the other through purified DNA fractions. Dr Joney De Souza will explain which fits your case, and whether pairing them adds value.
Profhilo is a stabilised hyaluronic acid best known for hydrating and firming facial skin. Polynucleotides for hair are formulated specifically for the follicular zone and act on scalp repair and inflammation. For hair concerns, Plinest Hair is the more targeted choice. Profhilo has its place for skin quality rather than hair density.
These two work at different depths. Polynucleotides are injected to repair the scalp from within. HydraFacial Keravive is a non-injectable cleanse that clears buildup and delivers nourishing serum at the surface. Our trained practitioners perform it. They complement each other, which is why both feature in our fuller hair programme rather than competing.
Hair Restore 360 is our doctor-led combination programme. It layers a HydraFacial Keravive scalp cleanse with the two regenerative injectables, PRP and polynucleotides, so the scalp is treated at the surface and within during one protocol. Dr Joney De Souza performs the injectable steps and our practitioners deliver the cleanse. You can read more on the Hair Restore 360 page.
The DNA fractions are drawn from purified fish DNA, commonly salmon or trout. The material is cleaned to a medical grade so the protein that could trigger a reaction is removed, leaving a highly purified, biocompatible repair signal. This is why the treatment is generally very well tolerated, though we still review any allergies at consultation.
Polynucleotides for hair at our Marylebone clinic start from £410 for a single session covering one area. A course of three is available, and pricing has an associate tier and a doctor-led tier delivered by Dr Joney De Souza. The number of areas affects the fee, so your exact price is confirmed at consultation, with no obligation to commit to a course first.
Minoxidil is a daily topical that widens blood vessels and prolongs the growth phase. Polynucleotides work at a deeper level, repairing scalp tissue and calming inflammation across a short course of injections rather than a daily routine. The two are compatible, and some patients use both. Which makes sense depends on your scalp and your preferences, something Dr Joney De Souza will talk through with you.
A hair transplant surgically relocates follicles into thinning zones and is the right answer where follicles are already lost. Polynucleotides aim to support follicles that are still present but underperforming. If your scalp shows advanced loss, Dr Joney De Souza will be honest with you. A surgical route may serve you better. Polynucleotides can then play a supportive role rather than a replacement one.
The safety record is well established and the purified DNA fractions are well tolerated by the scalp. The common effects are mild and short-lived: redness, small bumps and tenderness that settle within twenty four to forty eight hours. Rare risks, as with any injection, include bruising or infection, which is why a doctor-led setting and proper technique matter. Dr Joney De Souza reviews your suitability before treating you.
Yes, a consultation comes first, because the treatment only makes sense once we have confirmed what is driving your thinning. You can book your polynucleotides for hair session online, message us on WhatsApp or call the Marylebone clinic. We will always begin by assessing your scalp and agreeing a plan before your first injections.
Leave the scalp untouched for twelve hours, avoid washing your hair and heavy exercise that day, and keep away from saunas, steam and direct heat for forty eight hours. Hold off on styling products and topical treatments for a day. Redness or small bumps usually fade within a day or two, and Dr Joney De Souza gives you tailored aftercare at each session.
Our patients return to us year after year for natural, balanced results. Every review reflects our commitment to precision, safety and a personalised approach to aesthetic care.
I came for PRP hair loss treatment and so far really pleased with the results, have a few more sessions to go. Great clinic and lovely team.
Had my second session of PRP with micro needling today and I am so far very happy with my results. Dr De Souza is just the kindest man who really has the best intentions for you.
I highly recommend Dr. Joney and his clinic. I have been his patient for many years and he is definitely one of the best. His work is natural and subtle, and he always puts the patient’s interest first and will never try to upsell unnecessary treatments.
Dr Joney is the most wonderful Dr, kind and caring and highly experienced. I feel safe in his care and trust his opinion 100%.
