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Profhilo Treatment in London

Profhilo Structura in Marylebone at Dr Joney De Souza Clinic delivers advanced skin hydration and firmness. This next-generation treatment strengthens tissue, enhances elasticity and restores youthful structure.

Skin rejuvenation with Profhilo

Profhilo Treatment Summary

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No. of treatments
one treatment will give results which should last up-to 6 months
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Procedure time
45 minutes
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Back to work
Immediate
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Duration of results
Results may last up to 6 months months
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Anaesthetic
Given as needed
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Sensitivity period
Minimal
Price From
£450
*Prices vary based on number of treatment areas. View our full pricing information below.

Profhilo Skin Rejuvenation at Dr Joney De Souza Clinic in London

Profhilo is an advanced injectable treatment designed to improve skin quality, hydration and elasticity from within. Rather than adding volume or altering facial contours, Profhilo works by bio remodelling the skin, stimulating collagen and elastin while delivering deep, long lasting hydration.

At the Dr Joney De Souza Clinic in Marylebone, Profhilo is used to support natural rejuvenation. Treatments are carefully planned to enhance skin health, improve firmness and restore radiance while maintaining the integrity of your natural features.

Profhilo treatment ensures the skin looks more hydrated, fresher and younger, with an overall improved skin tone.

How can I book A Profhilo appointment?

How a Profhilo treatment works

Profhilo is carefully injected at strategic points beneath the skin. Once in place, the hyaluronic acid draws water into the deeper layers, delivering intense hydration and nourishing the skin from within. Over the following weeks, the presence of the hyaluronic acid also stimulates fibroblasts, which in turn boost the production of collagen and elastin.

This dual action results in:

  • Deep, lasting hydration

  • Improved elasticity and firmness

  • Smoother texture and tone

  • A more radiant, youthful complexion

Because the product gradually disperses and stimulates multiple types of collagen and elastin, the effects build naturally rather than instantly, creating a refined and authentic result.

Meet Dr Joney
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Your Profhilo Treatment Journey at Dr Joney De Souza Clinic

Every Profhilo treatment at Dr Joney De Souza Clinic begins with a thorough consultation. During this appointment, Dr Joney will take time to understand your skin goals, assess your hydration levels, elasticity and overall skin quality, and identify the areas that will benefit most from treatment. He will explain how Profhilo works, what improvements you can expect, and whether combining it with other treatments may help achieve optimal results.

Once your personalised plan is agreed, the skin is gently cleansed and a topical anaesthetic may be applied to ensure comfort. Using precise injection techniques, Dr Joney administers small amounts of Profhilo into a series of bio-aesthetic points just beneath the skin. The treatment is quick and designed to distribute the hyaluronic acid evenly across the tissue, stimulating collagen and elastin for a naturally refreshed, hydrated and lifted appearance. Discomfort is minimal and there is no significant downtime.

Aftercare

Following your Profhilo treatment, you can return to most daily activities straight away. You may notice slight redness, swelling or small visible bumps at the injection sites. These are completely normal and typically disappear within a few hours to 24 hours as the product begins to disperse through the skin.

Dr Joney will provide personalised aftercare advice, which may include avoiding strenuous exercise, heat treatments and applying pressure to the treated areas for 24 to 48 hours. As the active ingredients stimulate the skin’s natural repair processes, you will begin to notice improvements in hydration, smoothness and firmness over the following days. Results continue to develop after the second treatment session, usually performed four weeks later.

With regular maintenance every six months, your skin will remain brighter, more elastic and naturally rejuvenated, while maintaining the soft, subtle and refreshed look that Profhilo is known for.

Book a consultation
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Profhilo Frequently Asked Questions

Profhilo is an innovative skin remodelling treatment designed to improve hydration, elasticity and overall skin quality. It contains one of the highest concentrations of pure hyaluronic acid available and works by stimulating collagen and elastin production rather than adding volume or altering facial structure.

Profhilo is a non-surgical, quick and safe procedure. Small, precise injections are placed just beneath the skin where the product spreads naturally across the tissue, delivering deep hydration and improving firmness. It is especially effective for areas that show early signs of ageing such as the cheeks, lower face, neck and décolletage.

There is minimal downtime. You may experience slight redness, swelling or small bumps at the injection points, which typically settle within a few hours. Results develop gradually over the following weeks as the skin becomes smoother, tighter and more radiant. Most patients complete an initial course of two sessions four weeks apart, with results lasting around six months depending on individual skin condition and lifestyle.

Ask us your question

What can Profhilo do for me?

Profhilo works to improve your complexion by nourishing the dermal cells, resulting in radiant and rejuvenated skin. It can also help to combat the signs of ageing before they appear thanks to its intense hydrating capabilities. However, the most evident changes are seen when treating the appearance of lines, wrinkles, sagging, thinning and crepe-like skin. Profhilo effectively lifts and tightens the skin increasing firmness and elasticity with results that continue to improve for up to 6 months.

Who is suitable?

You will be invited for a medical consultation to assess your suitability for Profhilo treatment.

Which areas can Profhilo treat?

Profhilo is most commonly used on the face, but it can also treat:

  • Neck

  • Décolletage

  • Hands

  • Upper arms

  • Areas of crepey or lax skin

It is ideal for improving texture, hydration and elasticity.

How many Profhilo sessions do I need?

Most patients require an initial course of two treatments, spaced four weeks apart.
Some may benefit from a third session depending on their skin condition. Maintenance every 6 months is recommended for ongoing results.

Does Profhilo hurt?

Discomfort is minimal. The injections are quick, and most patients describe only a brief stinging sensation. A topical anaesthetic can be applied if needed.

Is there any downtime?

Downtime is very minimal. You may notice small bumps, redness or swelling at the injection points, which usually settle within a few hours. Normal daily activities can be resumed right away.

When will I see results?

You may notice early hydration improvements within a few days. The full skin remodelling effect develops 2–6 weeks after the second treatment, as collagen and elastin production increases.

How long do Profhilo results last?

Results typically last around 6 months, depending on age, skin quality and lifestyle. Regular maintenance treatments help maintain long-term skin improvement.

Can Profhilo be combined with other treatments?

Yes. Profhilo works beautifully alongside dermal fillers, Botox, microneedling, skin boosters and energy-based treatments. Dr Joney will advise on the best combination for your skin goals.

Is Profhilo suitable for everyone?

Profhilo is suitable for a wide range of skin types and ages, particularly those experiencing early signs of ageing, dehydration or loss of firmness. A consultation is required to ensure suitability, especially if you are pregnant, breastfeeding or have certain medical conditions.

Will Profhilo make me look different?

No. Profhilo does not change facial structure or add volume. It improves skin quality from within, giving a healthier, fresher and more radiant appearance while keeping your natural features intact.

 4.9 ★★★★★

Read our reviews

Our patients return to us year after year for natural, balanced results. Every review reflects our commitment to precision, safety and a personalised approach to aesthetic care.

I genuinely wouldn’t trust anyone else with my skin. Dr Joney de Souza remains my top recommendation for anyone seeking expert aesthetic care in London. He has a calm, professional manner and always takes the time to truly listen and understand what you’re hoping to achieve. His approach is natural and refined, you always leave looking like the best version of yourself, never overdone. The clinic is a beautiful, welcoming space in the heart of London, and the entire team is warm, knowledgeable, and highly professional. Dr Joney’s expertise and eye for detail are truly exceptional, and the results speak for themselves.
Daniele Bernardinetti
Daniele Bernardinetti
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I’ve known Dr. Joney de Souza for years and can’t recommend him highly enough. He’s a true expert in aesthetics — always professional, innovative, and genuinely caring. His treatments are subtle, natural, and always tailored to your needs. A standout in London’s aesthetic scene!
Osmar Pinheiro Bacelar Junior
Osmar Pinheiro Bacelar Junior
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I had treatment at Dr. Joney De Souza’s clinic one month ago and had a fantastic experience. Dr. De Souza was friendly, highly knowledgeable, and made me feel completely comfortable and at ease throughout the process. His great sense of humor also helped create a relaxed atmosphere. I’m really happy with the results and will definitely be coming back for regular visits. Highly recommend this clinic!
Daluna London
Daluna London
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The clinic is so very welcoming and really listens to how and what you would like to achieve, i have had several facial treatments and it has made such a difference to my confidence. David and everyone in the clinic are professional and experts in what they do, they treat you with a really personal service. My skin has never looked so clear or glowing .. I’ve had people stop and ask me what and where do I have my treatments .. thank you
Jayne Gates
Jayne Gates
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I had an excellent experience with Dr. Joney de Souza and his team. From start to finish, they were incredibly supportive, making me feel at ease throughout the entire process. Dr. Joney has both a sharp eye and a soft hand, striking the perfect balance between precision and gentleness. The team’s expertise speaks for itself, and their approach is as refined as it is reassuring. Highly recommended.

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Profhilo vs Profhilo Structura - what is the difference? 👉

Both are injectable treatments containing hyaluronic acid. Both are produced by the same manufacturer. And both deliver beautiful, natural results. But they are not the same treatment, and understanding the difference is important when it comes to choosing the right one for your skin.

🫧 Profhilo
Profhilo is a skin booster. Its primary purpose is to deeply hydrate the skin, improve overall skin quality and stimulate the production of collagen and elastin. It spreads through the tissue to treat a wide area, leaving the skin looking more radiant, plump and youthful. It is suitable for a broad range of patients and is particularly effective for anyone experiencing dullness, dehydration or a general loss of skin glow.

🫧 Profhilo Structura
Profhilo Structura is specifically designed to address skin laxity and loss of firmness. It contains a higher concentration of high molecular weight hyaluronic acid, which works to remodel the deeper structural layers of the skin, restoring lift, firmness and definition in areas where the skin has begun to lose its architecture over time. It is particularly effective for the cheeks, jawline and neck.

Which one is right for you?
If your primary concern is skin quality, hydration and radiance, Profhilo is likely the right starting point. If you are noticing a loss of firmness, definition or lift, Profhilo Structura may be the more appropriate choice. For many patients, the two work beautifully together as part of a combined treatment plan.

The best way to find out is a thorough consultation with one of our medics 🤍Your guide to radiant summer skin ☀️

Summer is here, and your skin needs a little extra love. Swipe through for everything you need to know to keep your skin glowing all season long 👉

PicoSure targets pigmentation, sun damage and uneven skin tone at a cellular level - giving you a clearer, brighter complexion just in time for summer.

SPF 50, every single day. Non-negotiable. UV rays are present rain or shine, and no treatment or product can undo the damage of unprotected sun exposure. Apply every morning and reapply every two hours outdoors. 

Skin boosters deliver deep hydration from within - improving elasticity, smoothing texture and creating that natural, lit-from-within glow that no topical product can replicate. 

📍Marylebone, London | 020 7043 0748 📱A Wonderful Review for Roma ✨

At Dr. Joney De Souza Skin & Laser Clinic, we believe that exceptional results are achieved through expertise, personalised care, and a genuine commitment to every patient’s journey.

We are delighted to share this wonderful feedback for Roma, whose knowledge, skill, and thoughtful approach continue to make a lasting impact on those she treats.

Roma takes the time to understand each individual’s skin concerns and goals, creating tailored treatment plans that deliver beautiful, confidence-boosting results. Her warm and professional manner ensures every patient feels comfortable, informed, and in the safest of hands throughout their journey.

Roma, thank you for the dedication and care you bring to every appointment. We are incredibly proud to have you as part of the clinic.

And to our lovely client, Victoria, thank you for your kind words and for trusting us with your skin health. We are thrilled that you achieved such great results and look forward to welcoming you back soon 🫶If you read one thing today, please let it be this 🤍

July is UV Safety Awareness Month, and as a skin and laser clinic, there is genuinely nothing we feel more passionately about than protecting the skin you’re in.

UV radiation is the leading cause of skin cancer worldwide. UVA rays silently penetrate deep into the skin every single day - breaking down collagen, causing dark spots, wrinkles and long-term cellular damage - while UVB rays trigger the DNA mutations that lead to skin cancer. And they are both present even on overcast days in the UK.

The reality? Nearly 9 in 10 melanomas are preventable. That statistic is both sobering and empowering because it means the choices you make today genuinely matter.

Swipe through for everything you need to know about why UV protection is non-negotiable, what unprotected exposure is doing to your skin right now, and exactly how to protect yourself this summer and beyond...

SPF 50 every morning. A wide-brimmed hat. Shade between 10am and 4pm. UV-blocking sunglasses. Lightweight cover-up. These aren’t just suggestions, they’re the steps that protect your skin, your health and your future 🖤

#uvsafety #uvsafetyawarenessmonth #melanomaawarenessProduct Spotlight of the Month - July ☀️

Meet your summer non-negotiable: ZO Skin Health Daily Sheer Broad-Spectrum SPF 50.

With July bringing longer days, stronger UV rays and more time spent outdoors, there has never been a more important time to make sure your SPF is doing its job properly - and this one delivers on every level.

Unlike your average sunscreen, Daily Sheer protects against the full spectrum of sun damage - including blue light from your phone and screens, and the deeper rays that most SPFs simply don’t block.

It also delivers 12 hours of antioxidant defence against everyday environmental damage, going far beyond what a standard SPF can offer.

The formula is completely non-greasy, water resistant for up to 40 minutes, and dries down to a sheer finish that sits beautifully under makeup. No white cast. No heavy residue. Just effortless, daily protection.

Awarded the Seal of Recommendation by the Skin Cancer Foundation (USA) - because this isn’t just skincare, it’s skin health 🤍

How can you find us?

Our clinic is located in Marylebone, London, in the heart of one of Central London’s most prestigious and renowned medical districts. Perfectly positioned for convenience and discretion, we are easily accessible from across the capital and beyond.

We welcome patients from Mayfair, Harley Street, Marylebone, Knightsbridge, Belgravia, Chelsea, Kensington, Fitzrovia and St John’s Wood, as well as international patients visiting London for specialist treatment.

Our location benefits from excellent transport connections, with close proximity to major Underground stations, mainline rail links and direct access to Heathrow, Gatwick and London City airports. Several secure parking facilities and convenient chauffeur drop-off points are available nearby, ensuring a seamless and comfortable visit.

Whether you are travelling from elsewhere in London, across the UK or internationally, our clinic offers a calm, private and exclusive setting in one of the world’s leading medical destinations.

Opening hours
Monday
9 am–6 pm
Tuesday
9 am–6 pm
Wednesday
9 am–6 pm
Thursday
9 am–6 pm
Friday
9 am–6 pm
Saturday
Closed
Sunday
Closed
Dr Joney De Souza
49 Blandford St, London W1U 7HH
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